Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin

Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin

BackgroundCurrent understanding of IL-22 in atopic dermatitis (AD) mostly relies on animal models, intracellular staining of polyclonally activated peripheral lymphocytes, and biological therapies.MethodsWe evaluated the IL-22 response to house dust mite (HDM) extract in 58 patients with moderate-to...

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Main Authors: Irene García-Jiménez, Lídia Sans-de San Nicolàs, Sandra Díez-Ribas, Laia Curto-Barredo, Marta Bertolín-Colilla, Ana Vivancos-Melenchón, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Anna Ryzhkova, Marta Ferran, Tali Czarnowicki, Ramon M. Pujol, Luis F. Santamaria-Babí
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
atopic dermatitis
CLA+ memory T cells
epidermal thickness
house dust mite
IgE
IL-22
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1599892/full
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