ADAM and ADAMTS Proteases in Hepatic Disorders
Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Mem...
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| Format: | Article |
| Language: | English |
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Troika Publisher
2019-02-01
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| Series: | Journal of Renal and Hepatic Disorders |
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| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/47 |
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| _version_ | 1849251250744328192 |
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| author | Dirk Schmidt-Arras Julia Bolik Janina EE Tirnitz-Parker |
| author_facet | Dirk Schmidt-Arras Julia Bolik Janina EE Tirnitz-Parker |
| author_sort | Dirk Schmidt-Arras |
| collection | DOAJ |
| description | Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes. This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology. |
| format | Article |
| id | doaj-art-aa6a783e26754c7ba23f2f8f3050ce91 |
| institution | Kabale University |
| issn | 2207-3744 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | Troika Publisher |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj-art-aa6a783e26754c7ba23f2f8f3050ce912025-08-20T03:57:00ZengTroika PublisherJournal of Renal and Hepatic Disorders2207-37442019-02-013110.15586/jrenhep.2019.47ADAM and ADAMTS Proteases in Hepatic DisordersDirk Schmidt-Arras0Julia Bolik1Janina EE Tirnitz-Parker2PhD, Christian-Albrechts-University Kiel, Institute of Biochemistry, Rudolf-Höber-Str.1, 24118 Kiel, GermanyChristian-Albrechts-University Kiel, Institute of Biochemistry, GermanySchool of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, AustraliaProteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes. This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology.https://jrenhep.com/index.php/jrenhep/article/view/47ADAMADAMTSmetzincin superfamilythrombotic thrombocytopenia purpuravon Willebrand Factor |
| spellingShingle | Dirk Schmidt-Arras Julia Bolik Janina EE Tirnitz-Parker ADAM and ADAMTS Proteases in Hepatic Disorders Journal of Renal and Hepatic Disorders ADAM ADAMTS metzincin superfamily thrombotic thrombocytopenia purpura von Willebrand Factor |
| title | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_full | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_fullStr | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_full_unstemmed | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_short | ADAM and ADAMTS Proteases in Hepatic Disorders |
| title_sort | adam and adamts proteases in hepatic disorders |
| topic | ADAM ADAMTS metzincin superfamily thrombotic thrombocytopenia purpura von Willebrand Factor |
| url | https://jrenhep.com/index.php/jrenhep/article/view/47 |
| work_keys_str_mv | AT dirkschmidtarras adamandadamtsproteasesinhepaticdisorders AT juliabolik adamandadamtsproteasesinhepaticdisorders AT janinaeetirnitzparker adamandadamtsproteasesinhepaticdisorders |