Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity
Abstract To investigate disparities in sensitisation to Staphylococcus aureus enterotoxin A/B (SEA/SEB) and olfactory function in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), those with CRS without nasal polyps (CRSsNP), and healthy controls who underwent septoplasty only....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-10-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-77459-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850179270176931840 |
|---|---|
| author | Minheon Kim Hee Sung Chae Dong Hwan Kwon Eun Kyung Jeon Young-Ha Lee Eun Jung Lee |
| author_facet | Minheon Kim Hee Sung Chae Dong Hwan Kwon Eun Kyung Jeon Young-Ha Lee Eun Jung Lee |
| author_sort | Minheon Kim |
| collection | DOAJ |
| description | Abstract To investigate disparities in sensitisation to Staphylococcus aureus enterotoxin A/B (SEA/SEB) and olfactory function in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), those with CRS without nasal polyps (CRSsNP), and healthy controls who underwent septoplasty only. We retrospectively reviewed the medical records of 388 subjects aged ≥ 8 years, collected between January 2021 and June 2023. We analysed patient demographics, medical history, serum IgE levels against staphylococcal enterotoxins (SEs), and serum total IgE levels against inhalant allergens. We performed olfactory and taste function tests in the participants to evaluate the relationship between olfactory function and SEs. Of 388 patients enrolled, 145 were healthy controls, 111 had CRSsNP, and 133 had CRSwNP. The prevalence of SEA/SEB positivity was significantly higher among the patients with CRSwNP than among those in the CRSsNP and healthy controls. The olfactory test results showed significant differences among the groups; anosmia was observed in 9.7% of healthy controls, 22.7% of patients with CRSsNP, and 45.1% of patients with CRSwNP. Olfactory threshold deterioration was evident in patients with CRS. Distinction and identification were more impaired in patients with CRSwNP than in those of the other groups. Finally, the olfactory function scores decreased as the serum levels of SEs increased. Sinusitis patients seem to suffer from perceiving odours, and patients with CRSwNP have difficulty distinguishing odours. Olfactory function test scores decreased in patients with a history of asthma, and as serum levels of staphylococcus enterotoxin and blood eosinophil percentage increase. Furthermore, our result suggests a potential role for SE sensitisation and eosinophil percentage in deteriorating olfaction, especially in patients with CRSwNP. |
| format | Article |
| id | doaj-art-aa688a58a1704d749ea9d3c79f016d16 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-aa688a58a1704d749ea9d3c79f016d162025-08-20T02:18:32ZengNature PortfolioScientific Reports2045-23222024-10-011411910.1038/s41598-024-77459-7Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivityMinheon Kim0Hee Sung Chae1Dong Hwan Kwon2Eun Kyung Jeon3Young-Ha Lee4Eun Jung Lee5Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineDepartment of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of MedicineAbstract To investigate disparities in sensitisation to Staphylococcus aureus enterotoxin A/B (SEA/SEB) and olfactory function in patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), those with CRS without nasal polyps (CRSsNP), and healthy controls who underwent septoplasty only. We retrospectively reviewed the medical records of 388 subjects aged ≥ 8 years, collected between January 2021 and June 2023. We analysed patient demographics, medical history, serum IgE levels against staphylococcal enterotoxins (SEs), and serum total IgE levels against inhalant allergens. We performed olfactory and taste function tests in the participants to evaluate the relationship between olfactory function and SEs. Of 388 patients enrolled, 145 were healthy controls, 111 had CRSsNP, and 133 had CRSwNP. The prevalence of SEA/SEB positivity was significantly higher among the patients with CRSwNP than among those in the CRSsNP and healthy controls. The olfactory test results showed significant differences among the groups; anosmia was observed in 9.7% of healthy controls, 22.7% of patients with CRSsNP, and 45.1% of patients with CRSwNP. Olfactory threshold deterioration was evident in patients with CRS. Distinction and identification were more impaired in patients with CRSwNP than in those of the other groups. Finally, the olfactory function scores decreased as the serum levels of SEs increased. Sinusitis patients seem to suffer from perceiving odours, and patients with CRSwNP have difficulty distinguishing odours. Olfactory function test scores decreased in patients with a history of asthma, and as serum levels of staphylococcus enterotoxin and blood eosinophil percentage increase. Furthermore, our result suggests a potential role for SE sensitisation and eosinophil percentage in deteriorating olfaction, especially in patients with CRSwNP.https://doi.org/10.1038/s41598-024-77459-7Smell (olfaction)Nasal polypsRhinosinusitisStaphylococcal enterotoxinsSensitisation |
| spellingShingle | Minheon Kim Hee Sung Chae Dong Hwan Kwon Eun Kyung Jeon Young-Ha Lee Eun Jung Lee Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity Scientific Reports Smell (olfaction) Nasal polyps Rhinosinusitis Staphylococcal enterotoxins Sensitisation |
| title | Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity |
| title_full | Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity |
| title_fullStr | Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity |
| title_full_unstemmed | Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity |
| title_short | Analysis of olfactory function in patients with chronic rhinosinusitis and Staphylococcus aureus enterotoxin positivity |
| title_sort | analysis of olfactory function in patients with chronic rhinosinusitis and staphylococcus aureus enterotoxin positivity |
| topic | Smell (olfaction) Nasal polyps Rhinosinusitis Staphylococcal enterotoxins Sensitisation |
| url | https://doi.org/10.1038/s41598-024-77459-7 |
| work_keys_str_mv | AT minheonkim analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity AT heesungchae analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity AT donghwankwon analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity AT eunkyungjeon analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity AT younghalee analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity AT eunjunglee analysisofolfactoryfunctioninpatientswithchronicrhinosinusitisandstaphylococcusaureusenterotoxinpositivity |