The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway

The assembly of RAB22A/TMEM33/RTN4 initiates a secretory ER-phagy pathway

Abstract Rafeesome, a newly identified multivesicular body (MVB)-like organelle, forms through the fusion of RAB22A-mediated ER-derived noncanonical autophagosomes with RAB22A-positive early endosomes. However, the mechanism underlying the formation of RAB22A-mediated noncanonical autophagosomes rem...

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Main Authors: Xueping Zheng, Dongmei Fang, Hao Shan, Beibei Xiao, Denghui Wei, Yingyi Ouyang, Lanqing Huo, Zhonghan Zhang, Yuanzhong Wu, Ruhua Zhang, Tiebang Kang, Ying Gao
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-025-00792-2
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