Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock

Integrating bioinformatics and machine learning for comprehensive analysis and validation of diagnostic biomarkers and immune cell infiltration characteristics in pediatric septic shock

Abstract This study aims to predict and diagnose pediatric septic shock through the screening of immune infiltration-related biomarkers. Three gene expression datasets were accessible from the Gene Expression Omnibus repository. The differentially expressed genes were identified using the R 4.3.2 (...

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Bibliographic Details
Main Authors: Peng Lyu, Na Xie, Xu-peng Shao, Shuai Xing, Xiao-yue Wang, Li-yun Duan, Xue Zhao, Jia-min Lu, Rong-fei Liu, Duo Zhang, Wei Lu, Kai-liang Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Pediatric septic shock
Bioinformatics
Machine-Learning
Biomarkers
Immune cell infiltration
Online Access:https://doi.org/10.1038/s41598-025-95028-4
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