Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors

Cell-based high-content approach for SARS-CoV-2 neutralization identifies unique monoclonal antibodies and PI3K pathway inhibitors

The sudden rise of the SARS-CoV-2 virus and the delay in development of effective therapeutics for mitigation made evident a need for ways to screen compounds that can block infection and prevent further pathogenesis and spread. However, identifying effective drugs that are efficacious against viral...

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Main Authors: Carly R. Cabel, Briana A. Guzman, Elaheh Alizadeh, Shuaizhi Li, Cameron Holberg, Chonlarat Wichaidit, Darren A. Cusanovich, Andrew L. Paek, Gregory R. J. Thatcher, Koenraad Van Doorslaer, Rachel S. Nargi, Rachel E. Sutton, Naveenchandra Suryadevara, James E. Crowe, Robert H. Carnahan, Samuel K. Campos, Curtis A. Thorne
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HTS
COVID
PI3K-AKT pathway
drug repurposing
HCA
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1538934/full
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