TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes

TRIM24 regulates chromatin remodeling and calcium dynamics in cardiomyocytes

Abstract Background Cardiomyocyte proteostasis and calcium homeostasis are critical for maintaining cardiac function, with their dysregulation contributing to cardiac hypertrophy and heart failure. The Tripartite Motif Protein 24 (TRIM24), a well-characterized chromatin reader and transcriptional re...

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Bibliographic Details
Main Authors: Marco Neu, Anushka Deshpande, Ankush Borlepawar, Elke Hammer, Ahmed Alameldeen, Phillipp Vöcking, Timon Seeger, Michael Hausmann, Norbert Frey, Ashraf Yusuf Rangrez
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
E3 ligase
TRIM24
Ubiquitin–proteasome system
Chromatin remodeling
Calcium homeostasis
Online Access:https://doi.org/10.1186/s12964-025-02323-8
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