Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis
ABSTRACT Atomically precise gold nanoclusters (NCs), possessing characteristics of molecules and nanoparticles, offer a promising solution to the challenges faced by existing pyroptosis inducers. Their abilities to catalyze the generation of reactive oxygen species and enhance radiosensitization pos...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Aggregate |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/agt2.70046 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849686316427509760 |
|---|---|
| author | Qiu‐Xu Zang Wei‐Tong Chen Wenjing Zhang Zhao‐Yang Wang Xi‐Yan Dong Runping Han Yanjuan Sang Xiaoyuan Chen Shuang‐Quan Zang |
| author_facet | Qiu‐Xu Zang Wei‐Tong Chen Wenjing Zhang Zhao‐Yang Wang Xi‐Yan Dong Runping Han Yanjuan Sang Xiaoyuan Chen Shuang‐Quan Zang |
| author_sort | Qiu‐Xu Zang |
| collection | DOAJ |
| description | ABSTRACT Atomically precise gold nanoclusters (NCs), possessing characteristics of molecules and nanoparticles, offer a promising solution to the challenges faced by existing pyroptosis inducers. Their abilities to catalyze the generation of reactive oxygen species and enhance radiosensitization position them as effective agents for activating pyroptosis. However, their catalytic efficiency is often compromised by limited geometrically accessible spaces around the active sites and the lack of suitable ligands. Leveraging the exposed metal centers in mononuclear organometallic catalysts and the tunable ligand of NCs, herein, ethynylferrocene (EFc) was utilized to amplify the peroxidase (POD)‐like activity of gold NCs by establishing the unshielded catalytic center and electron donor‐acceptor interaction between EFc and Au core. The resulting Au8Fe2 NCs with excellent POD‐mimicking activity could efficiently trigger pyroptosis by inducing intracellular oxidative stress. Moreover, the Au8Fe2 NCs, with their potential to deplete glutathione and enable magnetic resonance imaging, could also induce ferroptosis and serve as a diagnostic tool for tumors. All of these processes can be further potentiated by X‐ray radiation, taking advantage of the high atomic number of gold. This work opens new avenues for engineering the catalytic properties of NCs and broadens their potential applications in biomedicine. |
| format | Article |
| id | doaj-art-aa4d1b35cbac4fbe80e6639e05e3ff6c |
| institution | DOAJ |
| issn | 2692-4560 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj-art-aa4d1b35cbac4fbe80e6639e05e3ff6c2025-08-20T03:22:45ZengWileyAggregate2692-45602025-06-0166n/an/a10.1002/agt2.70046Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor PyroptosisQiu‐Xu Zang0Wei‐Tong Chen1Wenjing Zhang2Zhao‐Yang Wang3Xi‐Yan Dong4Runping Han5Yanjuan Sang6Xiaoyuan Chen7Shuang‐Quan Zang8Tianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaDepartment of Diagnostic Radiology, Yong Loo Lin School of Medicine National University of Singapore Singapore SingaporeTianjian Laboratory of Advanced Biomedical Sciences, Institute of Advanced Biomedical Sciences, State Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, College of Chemistry Zhengzhou University Zhengzhou ChinaABSTRACT Atomically precise gold nanoclusters (NCs), possessing characteristics of molecules and nanoparticles, offer a promising solution to the challenges faced by existing pyroptosis inducers. Their abilities to catalyze the generation of reactive oxygen species and enhance radiosensitization position them as effective agents for activating pyroptosis. However, their catalytic efficiency is often compromised by limited geometrically accessible spaces around the active sites and the lack of suitable ligands. Leveraging the exposed metal centers in mononuclear organometallic catalysts and the tunable ligand of NCs, herein, ethynylferrocene (EFc) was utilized to amplify the peroxidase (POD)‐like activity of gold NCs by establishing the unshielded catalytic center and electron donor‐acceptor interaction between EFc and Au core. The resulting Au8Fe2 NCs with excellent POD‐mimicking activity could efficiently trigger pyroptosis by inducing intracellular oxidative stress. Moreover, the Au8Fe2 NCs, with their potential to deplete glutathione and enable magnetic resonance imaging, could also induce ferroptosis and serve as a diagnostic tool for tumors. All of these processes can be further potentiated by X‐ray radiation, taking advantage of the high atomic number of gold. This work opens new avenues for engineering the catalytic properties of NCs and broadens their potential applications in biomedicine.https://doi.org/10.1002/agt2.70046catalytic performance | ferrocene | gold nanocluster | ligand engineering | pyroptosis |
| spellingShingle | Qiu‐Xu Zang Wei‐Tong Chen Wenjing Zhang Zhao‐Yang Wang Xi‐Yan Dong Runping Han Yanjuan Sang Xiaoyuan Chen Shuang‐Quan Zang Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis Aggregate catalytic performance | ferrocene | gold nanocluster | ligand engineering | pyroptosis |
| title | Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis |
| title_full | Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis |
| title_fullStr | Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis |
| title_full_unstemmed | Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis |
| title_short | Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis |
| title_sort | construction of active sites accessible au8 clusters for intensive tumor pyroptosis |
| topic | catalytic performance | ferrocene | gold nanocluster | ligand engineering | pyroptosis |
| url | https://doi.org/10.1002/agt2.70046 |
| work_keys_str_mv | AT qiuxuzang constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT weitongchen constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT wenjingzhang constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT zhaoyangwang constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT xiyandong constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT runpinghan constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT yanjuansang constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT xiaoyuanchen constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis AT shuangquanzang constructionofactivesitesaccessibleau8clustersforintensivetumorpyroptosis |