PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging
Abstract Background The Response Assessment in Neuro-Oncology (RANO) group recently reported PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0). The objective of this study was to evaluate the methodological application of these criteria for the amino acid [18F]-FDOPA radiotra...
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SpringerOpen
2025-04-01
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| Series: | EJNMMI Research |
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| Online Access: | https://doi.org/10.1186/s13550-025-01239-1 |
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| author | Guilhem Stien Adeline Zinsz Shamimeh Ahrari Luc Taillandier Marie Blonski Laetitia Imbert Timothée Zaragori Antoine Verger |
| author_facet | Guilhem Stien Adeline Zinsz Shamimeh Ahrari Luc Taillandier Marie Blonski Laetitia Imbert Timothée Zaragori Antoine Verger |
| author_sort | Guilhem Stien |
| collection | DOAJ |
| description | Abstract Background The Response Assessment in Neuro-Oncology (RANO) group recently reported PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0). The objective of this study was to evaluate the methodological application of these criteria for the amino acid [18F]-FDOPA radiotracer. Patients with confirmed glioma who underwent at least one baseline [18F]-FDOPA PET scan were retrospectively included. The PET RANO 1.0 criteria were evaluated regarding their methodological application. Patients with at least one follow-up PET scan were evaluated with the PET RANO 1.0 criteria as compared to the routine interpretation of two experts not using the PET RANO 1.0 criteria, defined as the reference. The different PET parameters included in the PET RANO 1.0 criteria were evaluated separately regarding their contribution. Results Ninety patients (52.0 ± 15.3 years old, 56% women) were included in this study regards to the methodology of application of the PET RANO 1.0 criteria, with 86% of patients presenting measurable diseases. Among these patients, 65 patients were evaluated for the comparison between the PET RANO 1.0 criteria and the expert interpretation: a concordance of 80%, equivalent for newly diagnosed and recurrent gliomas, as well as IDH-mutant vs. IDH-wildtype gliomas was found. The metabolic tumor volume represented the most contributive parameter (71% of cases) to the definition of response according to the PET RANO 1.0 criteria. Striatum infiltration, post-treatment related effects, measurable diseases criteria and thresholds for PET RANO 1.0 criteria were related to the cases discordances. Conclusion The PET RANO 1.0 criteria can be applied with [18F]-FDOPA imaging, with a reasonable concordance with results of an expert interpretation. Description of discordant cases should help to improve future PET RANO 1.0 criteria updating. |
| format | Article |
| id | doaj-art-aa4a1214fb2640a2bfd32b48082041c6 |
| institution | OA Journals |
| issn | 2191-219X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SpringerOpen |
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| series | EJNMMI Research |
| spelling | doaj-art-aa4a1214fb2640a2bfd32b48082041c62025-08-20T02:17:58ZengSpringerOpenEJNMMI Research2191-219X2025-04-0115111010.1186/s13550-025-01239-1PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imagingGuilhem Stien0Adeline Zinsz1Shamimeh Ahrari2Luc Taillandier3Marie Blonski4Laetitia Imbert5Timothée Zaragori6Antoine Verger7Department of Nuclear Medicine, CHRU of NancyDepartment of Nuclear Medicine, CHRU of NancyIADI, U1254, Inserm, Université de LorraineDepartment of Neuro-Oncology, CHRU of NancyDepartment of Neuro-Oncology, CHRU of NancyDepartment of Nuclear Medicine, CHRU of NancyIADI, U1254, Inserm, Université de LorraineDepartment of Nuclear Medicine, CHRU of NancyAbstract Background The Response Assessment in Neuro-Oncology (RANO) group recently reported PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0). The objective of this study was to evaluate the methodological application of these criteria for the amino acid [18F]-FDOPA radiotracer. Patients with confirmed glioma who underwent at least one baseline [18F]-FDOPA PET scan were retrospectively included. The PET RANO 1.0 criteria were evaluated regarding their methodological application. Patients with at least one follow-up PET scan were evaluated with the PET RANO 1.0 criteria as compared to the routine interpretation of two experts not using the PET RANO 1.0 criteria, defined as the reference. The different PET parameters included in the PET RANO 1.0 criteria were evaluated separately regarding their contribution. Results Ninety patients (52.0 ± 15.3 years old, 56% women) were included in this study regards to the methodology of application of the PET RANO 1.0 criteria, with 86% of patients presenting measurable diseases. Among these patients, 65 patients were evaluated for the comparison between the PET RANO 1.0 criteria and the expert interpretation: a concordance of 80%, equivalent for newly diagnosed and recurrent gliomas, as well as IDH-mutant vs. IDH-wildtype gliomas was found. The metabolic tumor volume represented the most contributive parameter (71% of cases) to the definition of response according to the PET RANO 1.0 criteria. Striatum infiltration, post-treatment related effects, measurable diseases criteria and thresholds for PET RANO 1.0 criteria were related to the cases discordances. Conclusion The PET RANO 1.0 criteria can be applied with [18F]-FDOPA imaging, with a reasonable concordance with results of an expert interpretation. Description of discordant cases should help to improve future PET RANO 1.0 criteria updating.https://doi.org/10.1186/s13550-025-01239-1PET RANO criteriaAmino acidPETGliomaFDOPA |
| spellingShingle | Guilhem Stien Adeline Zinsz Shamimeh Ahrari Luc Taillandier Marie Blonski Laetitia Imbert Timothée Zaragori Antoine Verger PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging EJNMMI Research PET RANO criteria Amino acid PET Glioma FDOPA |
| title | PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging |
| title_full | PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging |
| title_fullStr | PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging |
| title_full_unstemmed | PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging |
| title_short | PET-based response assessment criteria for diffuse gliomas (PET RANO 1.0): methodological application in [18F]-FDOPA PET imaging |
| title_sort | pet based response assessment criteria for diffuse gliomas pet rano 1 0 methodological application in 18f fdopa pet imaging |
| topic | PET RANO criteria Amino acid PET Glioma FDOPA |
| url | https://doi.org/10.1186/s13550-025-01239-1 |
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