Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary?
Introduction Thrombophilia (TP) has been proposed as a potential contributor to preeclampsia (PE). However, there is not a clear consensus on testing PE patients for TP due to contradictory evidences on this association. This study aims to identify what conditions of women with PE are associated wit...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296251330633 |
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| author | Ana Belén Gálvez MD Pedro Chorão MD Ernesto M Talegón MD María del Carmen Gilabert MD Amando Blanquer MD Fernando Ferrando MD, PhD Ana Cid MD Antonio Moscardó MD, PhD Saturnino Haya MD, PhD Santiago Bonanad MD |
| author_facet | Ana Belén Gálvez MD Pedro Chorão MD Ernesto M Talegón MD María del Carmen Gilabert MD Amando Blanquer MD Fernando Ferrando MD, PhD Ana Cid MD Antonio Moscardó MD, PhD Saturnino Haya MD, PhD Santiago Bonanad MD |
| author_sort | Ana Belén Gálvez MD |
| collection | DOAJ |
| description | Introduction Thrombophilia (TP) has been proposed as a potential contributor to preeclampsia (PE). However, there is not a clear consensus on testing PE patients for TP due to contradictory evidences on this association. This study aims to identify what conditions of women with PE are associated with acquired and hereditary TP, and, additionally, to build a model of TP probability using these characteristics. Material and Methods Retrospective unicentric analysis of women diagnosed with PE referred for TP testing between May 2019 and May 2024. Results In 95 women, 19 (20%) tested positive for TP, of which nine (47%) had antiphospholipid syndrome (APS), six (32%) were heterozygous for PT G20210A, two (11%) had ADAMTS13 deficiency, one (5%) had PS deficiency and one (5%) had heterozygous FV Leiden. In multivariate analysis, intrauterine growth retardation (IUGR; odds ratio (OR) 0.08, 95% confidence interval (CI) 0.01-0.55) and history of previous abortions (OR 0.22, 95%CI 0.06-0.96) were negatively associated with TP. The group of women with both, one or none of those traits showed respectively a TP prevalence of 0%, 15% and 32%. The higher the prevalence of TP, the lower the incidence of placental insufficiency and prematurity ( P < .05). Conclusions In pregnant women with PE, a history of previous abortions and IUGR were independently associated with the absence of TP. Women without these characteristics would probably benefit most from a Hematology consultation that includes a TP screening. A multinational standard TP screening framework for future studies is warranted to further our understanding of the role of TP in PE and to identify risk-groups for testing. |
| format | Article |
| id | doaj-art-aa48ffc3cb7c4fc2a9f61de950871be3 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-aa48ffc3cb7c4fc2a9f61de950871be32025-08-20T03:51:58ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-04-013110.1177/10760296251330633Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary?Ana Belén Gálvez MD0Pedro Chorão MD1Ernesto M Talegón MD2María del Carmen Gilabert MD3Amando Blanquer MD4Fernando Ferrando MD, PhD5Ana Cid MD6Antonio Moscardó MD, PhD7Saturnino Haya MD, PhD8Santiago Bonanad MD9 Hematology Department, , Valencia, Spain Hematology Research Group, Institut d’Investigació Sanitària La Fe, Valencia, Spain Hematology Department, , Valencia, Spain Hematology Department, , León, Spain Hematology Department, , Valencia, Spain Hematology Department, , Valencia, Spain Hematology Department, , Valencia, Spain Hematology Department, , Valencia, Spain Hematology Department, , Valencia, Spain Hematology Department, , Valencia, SpainIntroduction Thrombophilia (TP) has been proposed as a potential contributor to preeclampsia (PE). However, there is not a clear consensus on testing PE patients for TP due to contradictory evidences on this association. This study aims to identify what conditions of women with PE are associated with acquired and hereditary TP, and, additionally, to build a model of TP probability using these characteristics. Material and Methods Retrospective unicentric analysis of women diagnosed with PE referred for TP testing between May 2019 and May 2024. Results In 95 women, 19 (20%) tested positive for TP, of which nine (47%) had antiphospholipid syndrome (APS), six (32%) were heterozygous for PT G20210A, two (11%) had ADAMTS13 deficiency, one (5%) had PS deficiency and one (5%) had heterozygous FV Leiden. In multivariate analysis, intrauterine growth retardation (IUGR; odds ratio (OR) 0.08, 95% confidence interval (CI) 0.01-0.55) and history of previous abortions (OR 0.22, 95%CI 0.06-0.96) were negatively associated with TP. The group of women with both, one or none of those traits showed respectively a TP prevalence of 0%, 15% and 32%. The higher the prevalence of TP, the lower the incidence of placental insufficiency and prematurity ( P < .05). Conclusions In pregnant women with PE, a history of previous abortions and IUGR were independently associated with the absence of TP. Women without these characteristics would probably benefit most from a Hematology consultation that includes a TP screening. A multinational standard TP screening framework for future studies is warranted to further our understanding of the role of TP in PE and to identify risk-groups for testing.https://doi.org/10.1177/10760296251330633 |
| spellingShingle | Ana Belén Gálvez MD Pedro Chorão MD Ernesto M Talegón MD María del Carmen Gilabert MD Amando Blanquer MD Fernando Ferrando MD, PhD Ana Cid MD Antonio Moscardó MD, PhD Saturnino Haya MD, PhD Santiago Bonanad MD Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? Clinical and Applied Thrombosis/Hemostasis |
| title | Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? |
| title_full | Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? |
| title_fullStr | Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? |
| title_full_unstemmed | Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? |
| title_short | Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary? |
| title_sort | predicting thrombophilia in preeclampsia is universal testing necessary |
| url | https://doi.org/10.1177/10760296251330633 |
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