Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i>
This review evaluates the cytotoxic potential of the <i>Sesbania</i> genus, with a focus on <i>Sesbania sesban</i>, <i>Sesbania grandiflora</i>, and <i>Sesbania cannabina</i>. These species, known for their diverse phytochemical compositions, exhibit n...
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2025-01-01
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| author | Fatma Alzahraa Mokhtar Mariam Ahmed Aishah Saeed Al Dhanhani Serag Eldin I. Elbehairi Mohammad Y. Alfaifi Ali A. Shati Amal M. Fakhry |
| author_facet | Fatma Alzahraa Mokhtar Mariam Ahmed Aishah Saeed Al Dhanhani Serag Eldin I. Elbehairi Mohammad Y. Alfaifi Ali A. Shati Amal M. Fakhry |
| author_sort | Fatma Alzahraa Mokhtar |
| collection | DOAJ |
| description | This review evaluates the cytotoxic potential of the <i>Sesbania</i> genus, with a focus on <i>Sesbania sesban</i>, <i>Sesbania grandiflora</i>, and <i>Sesbania cannabina</i>. These species, known for their diverse phytochemical compositions, exhibit notable cytotoxic effects that suggest their utility in natural cancer treatments. Compounds such as quercetin, kaempferol, and sesbagrandiforian A and B have been highlighted for their strong antioxidant and antiproliferative effects, further emphasizing their therapeutic potential. The genus <i>Sesbania</i> exhibits a wide range of in vitro and in vivo bioactivities. Extensive research on <i>S. grandiflora</i> has uncovered mechanisms such as the activation of caspase cascades and the induction of apoptosis, attributed to its rich content of flavonoids and alkaloids. Notably, sesbanimides derived from <i>S. grandiflora</i> seeds have demonstrated potent cytotoxic effects by disrupting mitochondrial function. While <i>S. sesban</i> and <i>S. cannabina</i> have been less extensively studied, early findings highlight their potential through the inhibition of key cancer pathways and the identification of bioactive compounds such as galactomannan derivatives and 2-arylbenzofurans. Notably, the galactomannan derivatives from <i>S. sesban</i> exhibit significant immune-modulating properties. Additionally, nanoparticles synthesized from <i>Sesbania</i> species, including Cadmium oxide and PEGylated silver nanoparticles, have demonstrated promising cytotoxic activity by disrupting mitosis and enhancing immune responses. While further research is warranted, the <i>Sesbania</i> genus offers a promising basis for the development of innovative anticancer therapies. |
| format | Article |
| id | doaj-art-aa44234054344d71b9c2749c054c773e |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-aa44234054344d71b9c2749c054c773e2025-01-24T13:45:15ZengMDPI AGPharmaceuticals1424-82472025-01-011816410.3390/ph18010064Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i>Fatma Alzahraa Mokhtar0Mariam Ahmed1Aishah Saeed Al Dhanhani2Serag Eldin I. Elbehairi3Mohammad Y. Alfaifi4Ali A. Shati5Amal M. Fakhry6Fujairah Research Centre, Sakamkam Road, Fujairah 00000, United Arab EmiratesFaculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo 11835, EgyptFujairah Research Centre, Sakamkam Road, Fujairah 00000, United Arab EmiratesBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaBiology Department, Faculty of Science, King Khalid University, Abha 9004, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria 21511, EgyptThis review evaluates the cytotoxic potential of the <i>Sesbania</i> genus, with a focus on <i>Sesbania sesban</i>, <i>Sesbania grandiflora</i>, and <i>Sesbania cannabina</i>. These species, known for their diverse phytochemical compositions, exhibit notable cytotoxic effects that suggest their utility in natural cancer treatments. Compounds such as quercetin, kaempferol, and sesbagrandiforian A and B have been highlighted for their strong antioxidant and antiproliferative effects, further emphasizing their therapeutic potential. The genus <i>Sesbania</i> exhibits a wide range of in vitro and in vivo bioactivities. Extensive research on <i>S. grandiflora</i> has uncovered mechanisms such as the activation of caspase cascades and the induction of apoptosis, attributed to its rich content of flavonoids and alkaloids. Notably, sesbanimides derived from <i>S. grandiflora</i> seeds have demonstrated potent cytotoxic effects by disrupting mitochondrial function. While <i>S. sesban</i> and <i>S. cannabina</i> have been less extensively studied, early findings highlight their potential through the inhibition of key cancer pathways and the identification of bioactive compounds such as galactomannan derivatives and 2-arylbenzofurans. Notably, the galactomannan derivatives from <i>S. sesban</i> exhibit significant immune-modulating properties. Additionally, nanoparticles synthesized from <i>Sesbania</i> species, including Cadmium oxide and PEGylated silver nanoparticles, have demonstrated promising cytotoxic activity by disrupting mitosis and enhancing immune responses. While further research is warranted, the <i>Sesbania</i> genus offers a promising basis for the development of innovative anticancer therapies.https://www.mdpi.com/1424-8247/18/1/64<i>Sesbania</i>cytotoxicitygalactomannannanoparticlesnatural cancer treatmentssecondary metabolites |
| spellingShingle | Fatma Alzahraa Mokhtar Mariam Ahmed Aishah Saeed Al Dhanhani Serag Eldin I. Elbehairi Mohammad Y. Alfaifi Ali A. Shati Amal M. Fakhry Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> Pharmaceuticals <i>Sesbania</i> cytotoxicity galactomannan nanoparticles natural cancer treatments secondary metabolites |
| title | Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> |
| title_full | Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> |
| title_fullStr | Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> |
| title_full_unstemmed | Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> |
| title_short | Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i> |
| title_sort | distribution phytochemical insights and cytotoxic potential of the i sesbania i genus a comprehensive review of i sesbania grandiflora i i sesbania sesban i and i sesbania cannabina i |
| topic | <i>Sesbania</i> cytotoxicity galactomannan nanoparticles natural cancer treatments secondary metabolites |
| url | https://www.mdpi.com/1424-8247/18/1/64 |
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