Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Sesbania cannabina</i>
This review evaluates the cytotoxic potential of the <i>Sesbania</i> genus, with a focus on <i>Sesbania sesban</i>, <i>Sesbania grandiflora</i>, and <i>Sesbania cannabina</i>. These species, known for their diverse phytochemical compositions, exhibit n...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/18/1/64 |
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| Summary: | This review evaluates the cytotoxic potential of the <i>Sesbania</i> genus, with a focus on <i>Sesbania sesban</i>, <i>Sesbania grandiflora</i>, and <i>Sesbania cannabina</i>. These species, known for their diverse phytochemical compositions, exhibit notable cytotoxic effects that suggest their utility in natural cancer treatments. Compounds such as quercetin, kaempferol, and sesbagrandiforian A and B have been highlighted for their strong antioxidant and antiproliferative effects, further emphasizing their therapeutic potential. The genus <i>Sesbania</i> exhibits a wide range of in vitro and in vivo bioactivities. Extensive research on <i>S. grandiflora</i> has uncovered mechanisms such as the activation of caspase cascades and the induction of apoptosis, attributed to its rich content of flavonoids and alkaloids. Notably, sesbanimides derived from <i>S. grandiflora</i> seeds have demonstrated potent cytotoxic effects by disrupting mitochondrial function. While <i>S. sesban</i> and <i>S. cannabina</i> have been less extensively studied, early findings highlight their potential through the inhibition of key cancer pathways and the identification of bioactive compounds such as galactomannan derivatives and 2-arylbenzofurans. Notably, the galactomannan derivatives from <i>S. sesban</i> exhibit significant immune-modulating properties. Additionally, nanoparticles synthesized from <i>Sesbania</i> species, including Cadmium oxide and PEGylated silver nanoparticles, have demonstrated promising cytotoxic activity by disrupting mitosis and enhancing immune responses. While further research is warranted, the <i>Sesbania</i> genus offers a promising basis for the development of innovative anticancer therapies. |
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| ISSN: | 1424-8247 |