Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription

Celastrol promotes DNA damage and apoptosis in uterine corpus endometrial carcinoma via promotion of KAT2B-mediated RBPJ acetylation and repression of MCM4 transcription

Abstract Background Uterine corpus endometrial carcinoma (UCEC) is one of the most frequent female genital malignant tumors. Targeting DNA damage and cell apoptosis are regarded as effective ways for UCEC therapy. Celastrol is a natural anti-cancer product from the Celastraceae plant family, while i...

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Bibliographic Details
Main Authors: Lipeng Pei, Yan Zhu, Wenpeng Li, Bin Xu, Jingli Sun
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Medicine
Subjects:
Uterine corpus endometrial carcinoma
Celastrol
KAT2B
Acetylation
DNA damage
Apoptosis
Online Access:https://doi.org/10.1186/s10020-025-01082-z
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