RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation

The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and in vitro experiments for validation.

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Main Authors: Chen Shuo, Li Mengxing, Wang Jishi
Format: Article
Language:English
Published: De Gruyter 2025-03-01
Series:Open Medicine
Subjects:
Online Access:https://doi.org/10.1515/med-2025-1168
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author Chen Shuo
Li Mengxing
Wang Jishi
author_facet Chen Shuo
Li Mengxing
Wang Jishi
author_sort Chen Shuo
collection DOAJ
description The objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and in vitro experiments for validation.
format Article
id doaj-art-aa42bea4a8f64aac8afc5cc2245d7d97
institution DOAJ
issn 2391-5463
language English
publishDate 2025-03-01
publisher De Gruyter
record_format Article
series Open Medicine
spelling doaj-art-aa42bea4a8f64aac8afc5cc2245d7d972025-08-20T02:50:26ZengDe GruyterOpen Medicine2391-54632025-03-0120111365210.1515/med-2025-1168RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validationChen Shuo0Li Mengxing1Wang Jishi2Department of Hematology, Affiliated Medicine of Guizhou Medical University, Guiyang, 550001, ChinaDepartment of Hematology, Affiliated Medicine of Guizhou Medical University, Guiyang, 550001, ChinaDepartment of Hematology, Affiliated Medicine of Guizhou Medical University, Guiyang, 550001, ChinaThe objective of this research was to investigate the involvement of RAB39B in acute myeloid leukemia (AML) using bioinformatics analysis and in vitro experiments for validation.https://doi.org/10.1515/med-2025-1168rab39bimmune infiltrationm6a modificationapoptosisprognosisacute myeloid leukemia
spellingShingle Chen Shuo
Li Mengxing
Wang Jishi
RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
Open Medicine
rab39b
immune infiltration
m6a modification
apoptosis
prognosis
acute myeloid leukemia
title RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
title_full RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
title_fullStr RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
title_full_unstemmed RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
title_short RAB39B: A novel biomarker for acute myeloid leukemia identified via multi-omics and functional validation
title_sort rab39b a novel biomarker for acute myeloid leukemia identified via multi omics and functional validation
topic rab39b
immune infiltration
m6a modification
apoptosis
prognosis
acute myeloid leukemia
url https://doi.org/10.1515/med-2025-1168
work_keys_str_mv AT chenshuo rab39banovelbiomarkerforacutemyeloidleukemiaidentifiedviamultiomicsandfunctionalvalidation
AT limengxing rab39banovelbiomarkerforacutemyeloidleukemiaidentifiedviamultiomicsandfunctionalvalidation
AT wangjishi rab39banovelbiomarkerforacutemyeloidleukemiaidentifiedviamultiomicsandfunctionalvalidation