Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron

Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron

Prolonged exposure to volatile anesthetics may raise the risk of developing cognitive impairment by acting on gamma-a Aminobutyric acid A receptors (GABAAR). The dentate gyrus plays an important role in the hippocampus and has a high potential for neural plasticity. However, it is unknown whether pr...

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Bibliographic Details
Main Authors: Zhiqiang Yu, Xiaodan Chen, Zheng Liu, Ran Ding, Jin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Experimental Biology and Medicine
Subjects:
dentate gyrus
isoflurane
tonic current
GABAA receptor
knockout
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2024.10171/full
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