FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS
The paper describes the clinical, electroencephalographic (EEG), and neuroimaging features of focal epileptic myoclonus (FEM) and the results of therapy in patients with this type of seizure. The latter was identified in 2.5 % of the cases of epilepsy with onset beyond the age of 18 years (n = 1261)...
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ABV-press
2015-04-01
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| Series: | Русский журнал детской неврологии |
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| Online Access: | https://rjdn.abvpress.ru/jour/article/view/25 |
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| author | N. E. Kvaskova K. Yu. Mukhin M. B. Mironov |
| author_facet | N. E. Kvaskova K. Yu. Mukhin M. B. Mironov |
| author_sort | N. E. Kvaskova |
| collection | DOAJ |
| description | The paper describes the clinical, electroencephalographic (EEG), and neuroimaging features of focal epileptic myoclonus (FEM) and the results of therapy in patients with this type of seizure. The latter was identified in 2.5 % of the cases of epilepsy with onset beyond the age of 18 years (n = 1261). The age of onset of FЕМ was from 5 months to 23 years (mean 8.1 ± 1.6 years). The addition of secondary generalized seizures was stated in 90.3% of cases; that of focal motor seizures, epileptic aura, and negative FЕМ was seen in 64.5, 25.8, and 12.8 %, respectively. FЕМ was most commonly located in the flexor muscles of the upper extremities (22.6 %) and facial and upper limb muscles (25.6 %). The regional epileptoformactivity maximally located in the frontocentroparietal leads is a typical EEG pattern of FЕМ in all the patients. Magnetic resonance imaging most frequently revealed diffuse cortical and subcortical atrophy (29 %) and total cortical hemiatrophy (32 %). There was no case of complete remission of FЕМ. Monotherapy with antiepileptic drugs (AEDs) resulted in reduction of FЕМ in only 6.4 % of cases. During duo therapy, there was more than a 50 % reduction in FЕМ in 67.7 %. Our investigation has indicated that active FЕМ is a seizure type resistant to AEDs. This fact necessitates the detection of FЕМ at its early stages in order to predict the course of the disease and search for new therapies for epileptic syndromes associated with this type of seizures. |
| format | Article |
| id | doaj-art-aa3bc74f1bc144e897bffe9199cee005 |
| institution | DOAJ |
| issn | 2073-8803 2412-9178 |
| language | Russian |
| publishDate | 2015-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Русский журнал детской неврологии |
| spelling | doaj-art-aa3bc74f1bc144e897bffe9199cee0052025-08-20T02:56:09ZrusABV-pressРусский журнал детской неврологии2073-88032412-91782015-04-019361210.17650/2073-8803-2014-9-3-6-1219FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSISN. E. Kvaskova0K. Yu. Mukhin1M. B. Mironov2Svt. Luka’s Institute of Child Neurology and Epilepsy, MoscowSvt. Luka’s Institute of Child Neurology and Epilepsy, MoscowSvt. Luka’s Institute of Child Neurology and Epilepsy, MoscowThe paper describes the clinical, electroencephalographic (EEG), and neuroimaging features of focal epileptic myoclonus (FEM) and the results of therapy in patients with this type of seizure. The latter was identified in 2.5 % of the cases of epilepsy with onset beyond the age of 18 years (n = 1261). The age of onset of FЕМ was from 5 months to 23 years (mean 8.1 ± 1.6 years). The addition of secondary generalized seizures was stated in 90.3% of cases; that of focal motor seizures, epileptic aura, and negative FЕМ was seen in 64.5, 25.8, and 12.8 %, respectively. FЕМ was most commonly located in the flexor muscles of the upper extremities (22.6 %) and facial and upper limb muscles (25.6 %). The regional epileptoformactivity maximally located in the frontocentroparietal leads is a typical EEG pattern of FЕМ in all the patients. Magnetic resonance imaging most frequently revealed diffuse cortical and subcortical atrophy (29 %) and total cortical hemiatrophy (32 %). There was no case of complete remission of FЕМ. Monotherapy with antiepileptic drugs (AEDs) resulted in reduction of FЕМ in only 6.4 % of cases. During duo therapy, there was more than a 50 % reduction in FЕМ in 67.7 %. Our investigation has indicated that active FЕМ is a seizure type resistant to AEDs. This fact necessitates the detection of FЕМ at its early stages in order to predict the course of the disease and search for new therapies for epileptic syndromes associated with this type of seizures.https://rjdn.abvpress.ru/jour/article/view/25epilepsyfocal epileptic myoclonuskozhenvikov’s epilepsykozhevnikov–rasmussen’s encephalitisvideoelectroencephalographic monitoring |
| spellingShingle | N. E. Kvaskova K. Yu. Mukhin M. B. Mironov FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS Русский журнал детской неврологии epilepsy focal epileptic myoclonus kozhenvikov’s epilepsy kozhevnikov–rasmussen’s encephalitis videoelectroencephalographic monitoring |
| title | FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS |
| title_full | FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS |
| title_fullStr | FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS |
| title_full_unstemmed | FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS |
| title_short | FOCAL EPILEPTIC MYOCLONUS: DIFFERENTIAL DIAGNOSIS AND PROGNOSIS |
| title_sort | focal epileptic myoclonus differential diagnosis and prognosis |
| topic | epilepsy focal epileptic myoclonus kozhenvikov’s epilepsy kozhevnikov–rasmussen’s encephalitis videoelectroencephalographic monitoring |
| url | https://rjdn.abvpress.ru/jour/article/view/25 |
| work_keys_str_mv | AT nekvaskova focalepilepticmyoclonusdifferentialdiagnosisandprognosis AT kyumukhin focalepilepticmyoclonusdifferentialdiagnosisandprognosis AT mbmironov focalepilepticmyoclonusdifferentialdiagnosisandprognosis |