An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost

Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial. Methods. We review three recent randomized trials in anemia in CKD: C...

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Main Authors: Geoffrey Teehan, Robert L. Benz
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Anemia
Online Access:http://dx.doi.org/10.1155/2011/623673
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author Geoffrey Teehan
Robert L. Benz
author_facet Geoffrey Teehan
Robert L. Benz
author_sort Geoffrey Teehan
collection DOAJ
description Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial. Methods. We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT. Results. CHOIR (N=1432) was terminated early with more frequent death and cardiovascular outcomes in the higher Hb group (HR 1.34: 95% C.I. 1.03–1.74, P=.03). CREATE (N=603) showed no difference in primary cardiovascular endpoints. Stroke was more common in the higher Hb group (HR 1.92; 95% C.I. 1.38–2.68; P<.001) in TREAT (N=4038). Conclusions. There is no benefit to an Hb outside the 10–12 g/dL range in this population. To avoid transfusions and improve Quality of Life, ESAs should be used cautiously, especially in patients with Diabetes, CKD, risk factors for stroke, and ESA resistance.
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spelling doaj-art-aa3350508797495881803df4e72331c62025-02-03T06:00:05ZengWileyAnemia2090-12672090-12752011-01-01201110.1155/2011/623673623673An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and LostGeoffrey Teehan0Robert L. Benz1Department of Medicine, Division of Nephrology, Lankenau Medical Center, Suite 130 MOBW, 100 Lancaster Avenue, Wynnewood, PA 19096, USADepartment of Medicine, Division of Nephrology, Lankenau Medical Center, Suite 130 MOBW, 100 Lancaster Avenue, Wynnewood, PA 19096, USABackground. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial. Methods. We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT. Results. CHOIR (N=1432) was terminated early with more frequent death and cardiovascular outcomes in the higher Hb group (HR 1.34: 95% C.I. 1.03–1.74, P=.03). CREATE (N=603) showed no difference in primary cardiovascular endpoints. Stroke was more common in the higher Hb group (HR 1.92; 95% C.I. 1.38–2.68; P<.001) in TREAT (N=4038). Conclusions. There is no benefit to an Hb outside the 10–12 g/dL range in this population. To avoid transfusions and improve Quality of Life, ESAs should be used cautiously, especially in patients with Diabetes, CKD, risk factors for stroke, and ESA resistance.http://dx.doi.org/10.1155/2011/623673
spellingShingle Geoffrey Teehan
Robert L. Benz
An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
Anemia
title An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
title_full An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
title_fullStr An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
title_full_unstemmed An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
title_short An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost
title_sort update on the controversies in anemia management in chronic kidney disease lessons learned and lost
url http://dx.doi.org/10.1155/2011/623673
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