Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry
Abstract Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Me...
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BMC
2025-01-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-024-03471-x |
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| author | Tatiana Cobo-Ibáñez Ivan Castellví Ana Pros Marta Domínguez-Álvaro Laura Nuño-Nuño Julia Martínez-Barrio Vega Jovaní Fredeswinda Romero-Bueno Esther Ruiz-Lucea Eva Tomero Ernesto Trallero-Araguás Javier Narváez Jordi Camins-Fàbregas Alberto Ruiz-Román Jesús Loarce-Martos Susana Holgado-Pérez V Miguel Flores-Rodríguez Francisca Sivera Carolina Merino-Argumanez Antonio Juan-Mas Irene Altabás-González María Martín-López Joaquín María Belzunegui-Otano Carmen Carrasco-Cubero Mercedes Freire-González Iñigo Rúa-Figueroa Nuria Lozano-Rivas Julio David Suarez-Cuba Olga Martínez Rafaela Ortega-Castro Patricia Alcocer Alejandro Gómez-Gómez Olga Sánchez-Pernaute José Luis Tandaipan Irene Carrión-Barberà Chamaida Plasencia-Rodríguez Oihane Ibarguengoitia-Barrena Paola Vidal-Montal Vera Ortiz-Santamaria Noemi Garrido-Puñal Anne Riveros Esmeralda Delgado-Frías Juan Miguel López-Gómez Carmen Barbadillo José María Pego-Reigosa Beatriz E. Joven-Ibáñez Jesús Alejandro Valero-Jaimes Elena Naveda Ana Isabel Turrión-Nieves Daniel Seoane-Mato Francisco Javier Prado-Galbarro M Ángeles Puche-Larrubia |
| author_facet | Tatiana Cobo-Ibáñez Ivan Castellví Ana Pros Marta Domínguez-Álvaro Laura Nuño-Nuño Julia Martínez-Barrio Vega Jovaní Fredeswinda Romero-Bueno Esther Ruiz-Lucea Eva Tomero Ernesto Trallero-Araguás Javier Narváez Jordi Camins-Fàbregas Alberto Ruiz-Román Jesús Loarce-Martos Susana Holgado-Pérez V Miguel Flores-Rodríguez Francisca Sivera Carolina Merino-Argumanez Antonio Juan-Mas Irene Altabás-González María Martín-López Joaquín María Belzunegui-Otano Carmen Carrasco-Cubero Mercedes Freire-González Iñigo Rúa-Figueroa Nuria Lozano-Rivas Julio David Suarez-Cuba Olga Martínez Rafaela Ortega-Castro Patricia Alcocer Alejandro Gómez-Gómez Olga Sánchez-Pernaute José Luis Tandaipan Irene Carrión-Barberà Chamaida Plasencia-Rodríguez Oihane Ibarguengoitia-Barrena Paola Vidal-Montal Vera Ortiz-Santamaria Noemi Garrido-Puñal Anne Riveros Esmeralda Delgado-Frías Juan Miguel López-Gómez Carmen Barbadillo José María Pego-Reigosa Beatriz E. Joven-Ibáñez Jesús Alejandro Valero-Jaimes Elena Naveda Ana Isabel Turrión-Nieves Daniel Seoane-Mato Francisco Javier Prado-Galbarro M Ángeles Puche-Larrubia |
| author_sort | Tatiana Cobo-Ibáñez |
| collection | DOAJ |
| description | Abstract Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. Results A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p < 0.05), except for MYOACT muscular and creatine phosphokinase, for which no differences were recorded in ASA-positive patients. No differences were found between incident and prevalent cases for measures of damage. Values for the physical component of the SF-12 were higher in the prevalent cases (p < 0.05). The multivariate model was initially significant overall for the main activity outcomes. Positivity to ASAs was positively and negatively associated with the MYOACT index and MMT-8, respectively (p < 0.05), although no association was recorded with PhGA and extramuscular activity. Prevalent cases were negatively associated with the main outcomes of activity, except with MMT-8, for which the association was positive (p < 0.05). Conclusions The main activity outcomes validated in polymyositis and dermatomyositis could also be used in other subtypes of IIM, such as antisynthetase syndrome. Recent diagnosis is associated with greater disease activity, as assessed based on these activity outcomes. PhGA and extramuscular activity are not modified by ASA positivity, thus supporting their preferred use for assessing treatment response in IIM with ASAs. |
| format | Article |
| id | doaj-art-aa2dd0dafee54b2d8f2a02ee914fae89 |
| institution | Kabale University |
| issn | 1478-6362 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj-art-aa2dd0dafee54b2d8f2a02ee914fae892025-01-12T12:34:02ZengBMCArthritis Research & Therapy1478-63622025-01-0127111210.1186/s13075-024-03471-xDisease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registryTatiana Cobo-Ibáñez0Ivan Castellví1Ana Pros2Marta Domínguez-Álvaro3Laura Nuño-Nuño4Julia Martínez-Barrio5Vega Jovaní6Fredeswinda Romero-Bueno7Esther Ruiz-Lucea8Eva Tomero9Ernesto Trallero-Araguás10Javier Narváez11Jordi Camins-Fàbregas12Alberto Ruiz-Román13Jesús Loarce-Martos14Susana Holgado-Pérez15V Miguel Flores-Rodríguez16Francisca Sivera17Carolina Merino-Argumanez18Antonio Juan-Mas19Irene Altabás-González20María Martín-López21Joaquín María Belzunegui-Otano22Carmen Carrasco-Cubero23Mercedes Freire-González24Iñigo Rúa-Figueroa25Nuria Lozano-Rivas26Julio David Suarez-Cuba27Olga Martínez28Rafaela Ortega-Castro29Patricia Alcocer30Alejandro Gómez-Gómez31Olga Sánchez-Pernaute32José Luis Tandaipan33Irene Carrión-Barberà34Chamaida Plasencia-Rodríguez35Oihane Ibarguengoitia-Barrena36Paola Vidal-Montal37Vera Ortiz-Santamaria38Noemi Garrido-Puñal39Anne Riveros40Esmeralda Delgado-Frías41Juan Miguel López-Gómez42Carmen Barbadillo43José María Pego-Reigosa44Beatriz E. Joven-Ibáñez45Jesús Alejandro Valero-Jaimes46Elena Naveda47Ana Isabel Turrión-Nieves48Daniel Seoane-Mato49Francisco Javier Prado-Galbarro50M Ángeles Puche-Larrubia51Rheumatology Department, Hospital Universitario Infanta SofíaRheumatology Department, Hospital Universitari de la Santa Creu I Sant PauRheumatology Department, Hospital del MarUnidad de Investigación, Sociedad Española de ReumatologíaRheumatology Department, Hospital Universitario la PazRheumatology Department, Hospital General Universitario Gregorio MarañónRheumatology Department, Hospital General Universitario Dr BalmiRheumatology Department, Hospital Universitario Fundación Jiménez DíazRheumatology Department, Hospital Universitario de BasurtoRheumatology Department, Hospital Universitario La Princesa, IIS-IPRheumatology Department, Hospital Universitario Vall d ´HebronRheumatology Department, Hospital Universitario de Bellvitge, L’Hospitalet de LlobregatRheumatology Department, Hospital General de GranollersRheumatology Department, Hospital Universitario Virgen del RocíoRheumatology Department, Hospital Universitario Ramón y CajalRheumatology Department, Hospital Universitari Germans Trias i PujolRheumatology Department, Hospital Universitario de CanariasRheumatology Department, Dpt Medicina Clínica, Hospital General Universitario Elda, Universidad Miguel HernandezRheumatology Department, Hospital Universitario Puerta de Hierro MajadahondaRheumatology Department, Hospital Universitari Son LlàtzerRheumatology Department, University Hospital Complex of VigoRheumatology Department, Hospital Universitario 12 de OctubreRheumatology Department, Hospital Universitario DonostiaRheumatology Department, Complejo Hospitalario Universitario de BadajozRheumatology Department, Complejo Hospitalario Universitario A Coruña, A CoruñaRheumatology Department, Hospital de Gran Canaria Doctor NegrínRheumatology Department, Hospital Clínico Universitario Virgen de la ArrixacaRheumatology Department, Hospital Universitario Príncipe de AsturiasRheumatology Department, Hospital Complejo Asistencial Universitario de SalamancaRheumatology Department, Hospital Universitario Reina Sofía, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)Rheumatology Department, Hospital Universitario HM SanchinarroRheumatology Department, Hospital Universitario Infanta SofíaRheumatology Department, Hospital Universitario Fundación Jiménez DíazRheumatology Department, Hospital Universitari de la Santa Creu I Sant PauRheumatology Department, Hospital del MarRheumatology Department, Hospital Universitario la PazRheumatology Department, Hospital Universitario de BasurtoRheumatology Department, Hospital Universitario de Bellvitge, L’Hospitalet de LlobregatRheumatology Department, Hospital General de GranollersRheumatology Department, Hospital Universitario Virgen del RocíoRheumatology Department, Hospital Universitari Germans Trias i PujolRheumatology Department, Hospital Universitario de CanariasRheumatology Department, Dpt Medicina Clínica, Hospital General Universitario Elda, Universidad Miguel HernandezRheumatology Department, Hospital Universitario Puerta de Hierro MajadahondaRheumatology Department, University Hospital Complex of VigoRheumatology Department, Hospital Universitario 12 de OctubreRheumatology Department, Hospital Universitario DonostiaRheumatology Department, Hospital de Gran Canaria Doctor NegrínRheumatology Department, Hospital Complejo Asistencial Universitario de SalamancaUnidad de Investigación, Sociedad Española de ReumatologíaUnidad de Investigación, Sociedad Española de ReumatologíaRheumatology Department, Hospital Universitario Reina Sofía, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)Abstract Objective To evaluate the main outcomes of disease activity and their association with other measures of activity, damage, and quality of life in patients with idiopathic inflammatory myopathy (IIM) according to time since diagnosis and positivity to antisynthetase autoantibodies (ASAs). Methods Cross-sectional multicenter study within the Spanish Myo-Spain registry. Cases were classified as incident (≤ 12 months since diagnosis) and prevalent. The main outcomes of disease activity were the Myositis Disease Activity Assessment visual analogue scale (MYOACT), the Manual Muscle Test 8 (MMT-8), physician global activity (PhGA), and extramuscular activity. Other measures of activity, damage, and quality of life included patient global disease activity, MYOACT muscular, creatine phosphokinase, Health Assessment Questionnaire, physician and patient global damage, global damage of the Myositis Damage Index, and the 12-item Short-Form Health Survey (SF-12). We analyzed associations using a multivariate generalized linear model and a simple linear regression model. Results A total of 554 patients with different diagnostic subgroups of IIM were included (136 incident and 418 prevalent cases), with 215 ASA-positive patients (58 incident and 157 prevalent cases). All measures of disease activity were higher in the incident cases (p < 0.05), except for MYOACT muscular and creatine phosphokinase, for which no differences were recorded in ASA-positive patients. No differences were found between incident and prevalent cases for measures of damage. Values for the physical component of the SF-12 were higher in the prevalent cases (p < 0.05). The multivariate model was initially significant overall for the main activity outcomes. Positivity to ASAs was positively and negatively associated with the MYOACT index and MMT-8, respectively (p < 0.05), although no association was recorded with PhGA and extramuscular activity. Prevalent cases were negatively associated with the main outcomes of activity, except with MMT-8, for which the association was positive (p < 0.05). Conclusions The main activity outcomes validated in polymyositis and dermatomyositis could also be used in other subtypes of IIM, such as antisynthetase syndrome. Recent diagnosis is associated with greater disease activity, as assessed based on these activity outcomes. PhGA and extramuscular activity are not modified by ASA positivity, thus supporting their preferred use for assessing treatment response in IIM with ASAs.https://doi.org/10.1186/s13075-024-03471-xIdiopathic inflammatory myopathiesAntisynthetaseAutoantibodiesActivityDamage |
| spellingShingle | Tatiana Cobo-Ibáñez Ivan Castellví Ana Pros Marta Domínguez-Álvaro Laura Nuño-Nuño Julia Martínez-Barrio Vega Jovaní Fredeswinda Romero-Bueno Esther Ruiz-Lucea Eva Tomero Ernesto Trallero-Araguás Javier Narváez Jordi Camins-Fàbregas Alberto Ruiz-Román Jesús Loarce-Martos Susana Holgado-Pérez V Miguel Flores-Rodríguez Francisca Sivera Carolina Merino-Argumanez Antonio Juan-Mas Irene Altabás-González María Martín-López Joaquín María Belzunegui-Otano Carmen Carrasco-Cubero Mercedes Freire-González Iñigo Rúa-Figueroa Nuria Lozano-Rivas Julio David Suarez-Cuba Olga Martínez Rafaela Ortega-Castro Patricia Alcocer Alejandro Gómez-Gómez Olga Sánchez-Pernaute José Luis Tandaipan Irene Carrión-Barberà Chamaida Plasencia-Rodríguez Oihane Ibarguengoitia-Barrena Paola Vidal-Montal Vera Ortiz-Santamaria Noemi Garrido-Puñal Anne Riveros Esmeralda Delgado-Frías Juan Miguel López-Gómez Carmen Barbadillo José María Pego-Reigosa Beatriz E. Joven-Ibáñez Jesús Alejandro Valero-Jaimes Elena Naveda Ana Isabel Turrión-Nieves Daniel Seoane-Mato Francisco Javier Prado-Galbarro M Ángeles Puche-Larrubia Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry Arthritis Research & Therapy Idiopathic inflammatory myopathies Antisynthetase Autoantibodies Activity Damage |
| title | Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_full | Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_fullStr | Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_full_unstemmed | Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_short | Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry |
| title_sort | disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies data from the myo spain registry |
| topic | Idiopathic inflammatory myopathies Antisynthetase Autoantibodies Activity Damage |
| url | https://doi.org/10.1186/s13075-024-03471-x |
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