Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated?
Purpose: Octamer 4 (Oct-4) is a transcription factor which is required for the self-renewal and pluripotency of embryonic stem cells and germ cells. In this study, we tried to examine the association of expression of Oct-4 with lymph node metastasis in ductal carcinoma of the breast. Methods: The st...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=63;epage=66;aulast= |
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| _version_ | 1849395640483708928 |
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| author | Sangita A Vanik Shakti Kumar Yadav Aarzoo Jahan Sonam Kumar Pruthi Namrata Sarin Ratna Chopra Sompal Singh |
| author_facet | Sangita A Vanik Shakti Kumar Yadav Aarzoo Jahan Sonam Kumar Pruthi Namrata Sarin Ratna Chopra Sompal Singh |
| author_sort | Sangita A Vanik |
| collection | DOAJ |
| description | Purpose: Octamer 4 (Oct-4) is a transcription factor which is required for the self-renewal and pluripotency of embryonic stem cells and germ cells. In this study, we tried to examine the association of expression of Oct-4 with lymph node metastasis in ductal carcinoma of the breast. Methods: The study was conducted on a total of 45 cases of invasive ductal carcinoma of breast, no special type. Oct-4 expression was studied on paraffin-embedded sections by immunohistochemistry. Results: Oct-4 expression was seen in 22.2% of cases. No statistically significant association was found between the expression of Oct-4 and histological type, tumor size, histological grade, and lymph node metastasis. Of Oct-4 positive tumor, 80% of cases showed lymph node metastasis, as compared to 62.85% without Oct-4 expression. However, the association was statistically insignificant. Conclusion: Oct-4 expression can be a promising biomarker of carcinogenesis, metastatic potential, and prognosis of carcinoma breast. However, the study with larger sample size is needed to establish the clinicopathological potential of this biomarker. |
| format | Article |
| id | doaj-art-aa2db0e994d34a16be7d38c531488f3c |
| institution | Kabale University |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-aa2db0e994d34a16be7d38c531488f3c2025-08-20T03:39:32ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-01401636610.4103/ijmpo.ijmpo_154_18Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated?Sangita A VanikShakti Kumar YadavAarzoo JahanSonam Kumar PruthiNamrata SarinRatna ChopraSompal SinghPurpose: Octamer 4 (Oct-4) is a transcription factor which is required for the self-renewal and pluripotency of embryonic stem cells and germ cells. In this study, we tried to examine the association of expression of Oct-4 with lymph node metastasis in ductal carcinoma of the breast. Methods: The study was conducted on a total of 45 cases of invasive ductal carcinoma of breast, no special type. Oct-4 expression was studied on paraffin-embedded sections by immunohistochemistry. Results: Oct-4 expression was seen in 22.2% of cases. No statistically significant association was found between the expression of Oct-4 and histological type, tumor size, histological grade, and lymph node metastasis. Of Oct-4 positive tumor, 80% of cases showed lymph node metastasis, as compared to 62.85% without Oct-4 expression. However, the association was statistically insignificant. Conclusion: Oct-4 expression can be a promising biomarker of carcinogenesis, metastatic potential, and prognosis of carcinoma breast. However, the study with larger sample size is needed to establish the clinicopathological potential of this biomarker.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=63;epage=66;aulast=Breast carcinomalymph node metastasisOctamer 4 |
| spellingShingle | Sangita A Vanik Shakti Kumar Yadav Aarzoo Jahan Sonam Kumar Pruthi Namrata Sarin Ratna Chopra Sompal Singh Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? Indian Journal of Medical and Paediatric Oncology Breast carcinoma lymph node metastasis Octamer 4 |
| title | Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? |
| title_full | Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? |
| title_fullStr | Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? |
| title_full_unstemmed | Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? |
| title_short | Octamer 4 expression and lymph node metastasis in ductal carcinoma of breast: Are they associated? |
| title_sort | octamer 4 expression and lymph node metastasis in ductal carcinoma of breast are they associated |
| topic | Breast carcinoma lymph node metastasis Octamer 4 |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=63;epage=66;aulast= |
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