Volatile Compounds in Musk and Their Anti-Stroke Mechanisms
<b>Background/Objectives:</b> Musk is a widely used traditional Chinese medicine derived from musk deer that has the pharmacological effects of “activating blood dredging collateral” and “consciousness-restoring resuscitation”. Its volatile compounds (VCs) play a key role in these effect...
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2025-03-01
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| author | Chengli Zheng Xin Shi Qinling Yang Zhongkun Cai Xiao Wang Liuqing Yang Xue Bai Xiuxiang Meng Diyan Li Hang Jie |
| author_facet | Chengli Zheng Xin Shi Qinling Yang Zhongkun Cai Xiao Wang Liuqing Yang Xue Bai Xiuxiang Meng Diyan Li Hang Jie |
| author_sort | Chengli Zheng |
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| description | <b>Background/Objectives:</b> Musk is a widely used traditional Chinese medicine derived from musk deer that has the pharmacological effects of “activating blood dredging collateral” and “consciousness-restoring resuscitation”. Its volatile compounds (VCs) play a key role in these effects, especially in the treatment of stroke. However, there have been no comprehensive studies on the differences in the VCs of these different musks. This study investigated the differences in the VCs of different musks and the potential targets and mechanisms of action for stroke. <b>Methods:</b> Different musks were studied via GC–MS, and the potential targets and mechanisms of VCs associated with stroke were investigated using network pharmacology. <b>Results:</b> A total of 99 VCs were detected in 79 musk samples. The most important VCs of different colours and forms were muscone, phenol, acetic acid, and isovaleric acid. Further study revealed that the change in organic acids and ketones was the cause of the significant difference between white musk and other types of musk. In addition, network pharmacological analyses identified 180 potential targets of the major volatile compounds of musk associated with stroke, and five key targets (<i>SRC</i>, <i>EGFR</i>, <i>ESR1</i>, <i>PTGS2</i>, and <i>DRD2</i>). Enrichment analysis showed that these key targets play an important role in neural related pathways. The molecular docking results confirmed that the key targets can effectively bind with the main VCs (muscone and phenol). <b>Conclusions:</b> These findings provide valuable insights into the distinct volatile compositions of various types of musk and underscore the significant potential of volatile compounds (VCs) in stroke treatment. |
| format | Article |
| id | doaj-art-aa2cc891eb4642679be9bec5f9897c75 |
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| issn | 2218-1989 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-aa2cc891eb4642679be9bec5f9897c752025-08-20T01:49:05ZengMDPI AGMetabolites2218-19892025-03-0115318110.3390/metabo15030181Volatile Compounds in Musk and Their Anti-Stroke MechanismsChengli Zheng0Xin Shi1Qinling Yang2Zhongkun Cai3Xiao Wang4Liuqing Yang5Xue Bai6Xiuxiang Meng7Diyan Li8Hang Jie9Sichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu 611845, ChinaSichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu 611845, ChinaJinfo Mountain Forestry Ecosystem of Chongqing Observation and Research Station, Chongqing Institute of Medicinal Plant Cultivation, Chongqing 408435, ChinaSchool of Pharmacy, Chengdu University, Chengdu 610106, ChinaShimadzu Enterprise Management (China) Co., Ltd., Chengdu 610023, ChinaSichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu 611845, ChinaSchool of Pharmacy, Chengdu University, Chengdu 610106, ChinaSchool of Ecology and Environment, Renmin University of China, Beijing 100872, ChinaSchool of Pharmacy, Chengdu University, Chengdu 610106, ChinaJinfo Mountain Forestry Ecosystem of Chongqing Observation and Research Station, Chongqing Institute of Medicinal Plant Cultivation, Chongqing 408435, China<b>Background/Objectives:</b> Musk is a widely used traditional Chinese medicine derived from musk deer that has the pharmacological effects of “activating blood dredging collateral” and “consciousness-restoring resuscitation”. Its volatile compounds (VCs) play a key role in these effects, especially in the treatment of stroke. However, there have been no comprehensive studies on the differences in the VCs of these different musks. This study investigated the differences in the VCs of different musks and the potential targets and mechanisms of action for stroke. <b>Methods:</b> Different musks were studied via GC–MS, and the potential targets and mechanisms of VCs associated with stroke were investigated using network pharmacology. <b>Results:</b> A total of 99 VCs were detected in 79 musk samples. The most important VCs of different colours and forms were muscone, phenol, acetic acid, and isovaleric acid. Further study revealed that the change in organic acids and ketones was the cause of the significant difference between white musk and other types of musk. In addition, network pharmacological analyses identified 180 potential targets of the major volatile compounds of musk associated with stroke, and five key targets (<i>SRC</i>, <i>EGFR</i>, <i>ESR1</i>, <i>PTGS2</i>, and <i>DRD2</i>). Enrichment analysis showed that these key targets play an important role in neural related pathways. The molecular docking results confirmed that the key targets can effectively bind with the main VCs (muscone and phenol). <b>Conclusions:</b> These findings provide valuable insights into the distinct volatile compositions of various types of musk and underscore the significant potential of volatile compounds (VCs) in stroke treatment.https://www.mdpi.com/2218-1989/15/3/181<i>Moschus berezovskii</i>muskvolatile compoundsstrokeGC-MS |
| spellingShingle | Chengli Zheng Xin Shi Qinling Yang Zhongkun Cai Xiao Wang Liuqing Yang Xue Bai Xiuxiang Meng Diyan Li Hang Jie Volatile Compounds in Musk and Their Anti-Stroke Mechanisms Metabolites <i>Moschus berezovskii</i> musk volatile compounds stroke GC-MS |
| title | Volatile Compounds in Musk and Their Anti-Stroke Mechanisms |
| title_full | Volatile Compounds in Musk and Their Anti-Stroke Mechanisms |
| title_fullStr | Volatile Compounds in Musk and Their Anti-Stroke Mechanisms |
| title_full_unstemmed | Volatile Compounds in Musk and Their Anti-Stroke Mechanisms |
| title_short | Volatile Compounds in Musk and Their Anti-Stroke Mechanisms |
| title_sort | volatile compounds in musk and their anti stroke mechanisms |
| topic | <i>Moschus berezovskii</i> musk volatile compounds stroke GC-MS |
| url | https://www.mdpi.com/2218-1989/15/3/181 |
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