Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy
Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory antican...
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240525000224 |
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| author | Haonan Ma Yifan Jin Jintao Li Xuedong Xiao Chengfei Liu Wei Tian |
| author_facet | Haonan Ma Yifan Jin Jintao Li Xuedong Xiao Chengfei Liu Wei Tian |
| author_sort | Haonan Ma |
| collection | DOAJ |
| description | Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory anticancer activity because of the relatively low loading capacities, inconsistent reproducibility, and unpredictable release kinetics. In this study, we reported the construction of ruthenium (II)-coordinated supramolecular drug self-delivery systems. These systems are proposed to provide a stable and efficient transport platform for delivering drugs, thereby enhancing the effectiveness of combination chemotherapy. Ruthenium (II)-coordinated supramolecular polymer (RuSP) was first formed through host-guest interaction between β-cyclodextrin (β-CD) units grafted onto a hyaluronic acid chain (HA-CD) and (Benzene)Ru(curcuminato)Cl (Ru-Cur). The obtained RuSP then further self-assembled into ruthenium (II)-coordinated supramolecular drug self-assemblies (RuSDSAs). Upon internalization into cancer cells, RuSDSAs could be effectively degraded in acidic tumor microenvironment as for the smart dissociation of host-guest interaction, allowing for the controlled release of Ru-Cur and enhancing the efficacy of combination chemotherapy. Biological evaluation demonstrated that RuSDSAs achieved good anticancer effects and are biologically safe. |
| format | Article |
| id | doaj-art-aa27a60b455f4c5abe581f60b179dbcf |
| institution | Kabale University |
| issn | 2667-2405 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Supramolecular Materials |
| spelling | doaj-art-aa27a60b455f4c5abe581f60b179dbcf2025-08-20T03:25:29ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052025-12-01410011310.1016/j.supmat.2025.100113Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapyHaonan Ma0Yifan Jin1Jintao Li2Xuedong Xiao3Chengfei Liu4Wei Tian5Shaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, PR ChinaShaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, PR ChinaShaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, PR ChinaDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, PR ChinaShaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, PR China; Corresponding authors.Shaanxi Key Laboratory of Macromolecular Science and Technology, Xi’an Key Laboratory of Hybrid Luminescent Materials and Photonic Device, MOE Key Laboratory of Material Physics and Chemistry under Extraordinary Conditions, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi’an, 710072, Shaanxi, PR China; Corresponding authors.Combination chemotherapy has been considered a crucial approach in cancer treatment to address the limitations of traditional single-drug therapy. However, the common strategies that encapsulate therapeutic agents with different mechanisms into a single “package” often lead to unsatisfactory anticancer activity because of the relatively low loading capacities, inconsistent reproducibility, and unpredictable release kinetics. In this study, we reported the construction of ruthenium (II)-coordinated supramolecular drug self-delivery systems. These systems are proposed to provide a stable and efficient transport platform for delivering drugs, thereby enhancing the effectiveness of combination chemotherapy. Ruthenium (II)-coordinated supramolecular polymer (RuSP) was first formed through host-guest interaction between β-cyclodextrin (β-CD) units grafted onto a hyaluronic acid chain (HA-CD) and (Benzene)Ru(curcuminato)Cl (Ru-Cur). The obtained RuSP then further self-assembled into ruthenium (II)-coordinated supramolecular drug self-assemblies (RuSDSAs). Upon internalization into cancer cells, RuSDSAs could be effectively degraded in acidic tumor microenvironment as for the smart dissociation of host-guest interaction, allowing for the controlled release of Ru-Cur and enhancing the efficacy of combination chemotherapy. Biological evaluation demonstrated that RuSDSAs achieved good anticancer effects and are biologically safe.http://www.sciencedirect.com/science/article/pii/S2667240525000224Supramolecular polymersSupramolecular drug self-assembliesCombinationChemotherapy |
| spellingShingle | Haonan Ma Yifan Jin Jintao Li Xuedong Xiao Chengfei Liu Wei Tian Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy Supramolecular Materials Supramolecular polymers Supramolecular drug self-assemblies Combination Chemotherapy |
| title | Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy |
| title_full | Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy |
| title_fullStr | Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy |
| title_full_unstemmed | Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy |
| title_short | Ruthenium (II)-coordinated supramolecular drug self-assembly for efficient combination chemotherapy |
| title_sort | ruthenium ii coordinated supramolecular drug self assembly for efficient combination chemotherapy |
| topic | Supramolecular polymers Supramolecular drug self-assemblies Combination Chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2667240525000224 |
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