Altered IgG <i>N</i>-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab <i>N</i>-Glycans

Altered IgG <i>N</i>-Glycosylation at Onset of Type 1 Diabetes in Children Is Predominantly Driven by Changes in the Fab <i>N</i>-Glycans

<b>Background</b>: <i>N</i>-glycosylation is a post-translational modification involving the attachment of oligosaccharides to proteins and is known to influence immunoglobulin G (IgG) effector functions and even antigen binding. IgG contains an evolutionarily conserved <i...

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Bibliographic Details
Main Authors: Branimir Plavša, Najda Rudman, Flemming Pociot, Olga Gornik
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomedicines
Subjects:
<i>N</i>-glycosylation
immunoglobulin G
type 1 diabetes
Fc
Fab
IdeS
Online Access:https://www.mdpi.com/2227-9059/13/5/1206
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