Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer

Integration of single-cell RNA and bulk RNA sequencing revealed malignant ductal cell heterogeneity and prognosis signatures in pancreatic cancer

IntroductionPancreatic cancer is a highly malignant tumor of the digestive system with a dismal prognosis. Despite advances in diagnosis and treatment, overall survival remains extremely low. Early diagnostic markers and an improved understanding of tumor-microenvironment interactions are essential...

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Bibliographic Details
Main Authors: Haiyang Du, Gao Si, Jiqing Si, Xuejie Song, Fuchun Si
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
pancreatic cancer
tumor microenvironment
CTSV
macrophages
CXCL14-CXCR4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1579184/full
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