Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B
Previous viral hepatitis B increases the risk of cirrhosis in various chronic liver diseases.Aim. Assessment of association between previous hepatitis B and the severity of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).Materials and methods. A single-centre cross-sectional...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2020-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/472 |
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| author | S. N. Batskikh E. V. Vinnitskaya E. S. Sbikina Zh. V. Borunova A. S. Dorofeev Yu. G. Sandler |
| author_facet | S. N. Batskikh E. V. Vinnitskaya E. S. Sbikina Zh. V. Borunova A. S. Dorofeev Yu. G. Sandler |
| author_sort | S. N. Batskikh |
| collection | DOAJ |
| description | Previous viral hepatitis B increases the risk of cirrhosis in various chronic liver diseases.Aim. Assessment of association between previous hepatitis B and the severity of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).Materials and methods. A single-centre cross-sectional trial included 110 HBsAg- and anti-HCV-negative patients with confirmed NAFLD (median (IQR) age 60 (53-66) years). Obesity, type 2 diabetes and dyslipidemia were in 78 (70.9%), 64 (58.2%) and 77 (70%) individuals, respectively. To confirm previous and occult hepatitis B virus (HBV) infection, blood of all participants was examined for anti-HBc (IgG) and HBV DNA. Liver biopsy was performed in 35 patients (31.8%), other patients had transient elastography with steatometry and/or a serum FibroMax™ assay (FibroTest+SteatoTest+NashTest).Results. In 85 patients, liver fibrosis was scored F0-F2 with METAVIR, 25 persons had severe fibrosis (F4 in 23, F3 in 2). Patients with severe fibrosis were significantly older than persons with F0-F2 and had more frequent type 2 diabetes. Anti-HBc was detected in 10 of 25 (40%) patients with F3-F4 and in 7 of 85 (8.2%) persons with F0-F2 (p <0.001). None of anti-HBc-positive individuals had HBV DNA in blood. Presence of anti-HBc was the major factor directly associated with severe liver fibrosis (OR 7.339; 95% CI 2.189-24.604; p = 0.001).Conclusion. Anti-HBc-positive patients with NAFLD have a much higher risk of severe liver fibrosis compared to patients without previous viral hepatitis B. |
| format | Article |
| id | doaj-art-aa1405786980402bacc543826c0dcbcf |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-aa1405786980402bacc543826c0dcbcf2025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-09-01304283410.22416/1382-4376-2020-30-4-28-34369Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis BS. N. Batskikh0E. V. Vinnitskaya1E. S. Sbikina2Zh. V. Borunova3A. S. Dorofeev4Yu. G. Sandler5Loginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterLoginov Moscow Clinical Scientific CenterPrevious viral hepatitis B increases the risk of cirrhosis in various chronic liver diseases.Aim. Assessment of association between previous hepatitis B and the severity of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).Materials and methods. A single-centre cross-sectional trial included 110 HBsAg- and anti-HCV-negative patients with confirmed NAFLD (median (IQR) age 60 (53-66) years). Obesity, type 2 diabetes and dyslipidemia were in 78 (70.9%), 64 (58.2%) and 77 (70%) individuals, respectively. To confirm previous and occult hepatitis B virus (HBV) infection, blood of all participants was examined for anti-HBc (IgG) and HBV DNA. Liver biopsy was performed in 35 patients (31.8%), other patients had transient elastography with steatometry and/or a serum FibroMax™ assay (FibroTest+SteatoTest+NashTest).Results. In 85 patients, liver fibrosis was scored F0-F2 with METAVIR, 25 persons had severe fibrosis (F4 in 23, F3 in 2). Patients with severe fibrosis were significantly older than persons with F0-F2 and had more frequent type 2 diabetes. Anti-HBc was detected in 10 of 25 (40%) patients with F3-F4 and in 7 of 85 (8.2%) persons with F0-F2 (p <0.001). None of anti-HBc-positive individuals had HBV DNA in blood. Presence of anti-HBc was the major factor directly associated with severe liver fibrosis (OR 7.339; 95% CI 2.189-24.604; p = 0.001).Conclusion. Anti-HBc-positive patients with NAFLD have a much higher risk of severe liver fibrosis compared to patients without previous viral hepatitis B.https://www.gastro-j.ru/jour/article/view/472hepatitis bcirrhosisnon-alcoholic fatty liver disease |
| spellingShingle | S. N. Batskikh E. V. Vinnitskaya E. S. Sbikina Zh. V. Borunova A. S. Dorofeev Yu. G. Sandler Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatitis b cirrhosis non-alcoholic fatty liver disease |
| title | Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B |
| title_full | Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B |
| title_fullStr | Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B |
| title_full_unstemmed | Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B |
| title_short | Risk of Cirrhosis in Patients with Non-alcoholic Fatty Liver Disease and Previous Viral Hepatitis B |
| title_sort | risk of cirrhosis in patients with non alcoholic fatty liver disease and previous viral hepatitis b |
| topic | hepatitis b cirrhosis non-alcoholic fatty liver disease |
| url | https://www.gastro-j.ru/jour/article/view/472 |
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