Granulocyte-macrophage colony-stimulating factor may contribute to spondyloarthritis development in HLA-B27 transgenic rat by affecting conventional dendritic cells function

Granulocyte-macrophage colony-stimulating factor may contribute to spondyloarthritis development in HLA-B27 transgenic rat by affecting conventional dendritic cells function

Abstract Background Spondyloarthritis (SpA) is a chronic inflammatory disorder with axial and peripheral manifestations. A strong association between HLA-B27 and SpA has been known for more than 50 years. Remarkably, HLA-B27 and human β2-microglubulin transgenic rats (B27 rat) develop manifestations...

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Main Authors: Amel Ait Ali Said, Chiara Rizzo, Hendrick Mambu Mambueni, Félicie Costantino, Maxime Breban, Simon Glatigny
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Arthritis Research & Therapy
Online Access:https://doi.org/10.1186/s13075-025-03586-9
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