BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications
BODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, and remarkable photostability. This review synthesize...
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2025-04-01
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| author | Panangattukara Prabhakaran Praveen Kumar Shivanjali Saxena Rakesh Joshi |
| author_facet | Panangattukara Prabhakaran Praveen Kumar Shivanjali Saxena Rakesh Joshi |
| author_sort | Panangattukara Prabhakaran Praveen Kumar |
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| description | BODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, and remarkable photostability. This review synthesizes the recent advancements in BODIPY dyes, focusing on their deployment in biological imaging and therapy. The exceptional ability of BODIPY dyes to selectively stain cellular structures enables precise visualization of lipids, proteins, and nucleic acids within live and tumor cells, thereby facilitating enhanced understanding of biochemical processes. Moreover, BODIPY derivatives are increasingly utilized in Photodynamic therapy (PDT) and Photothermal therapies (PTT) for targeting cancer cells, where their capability to generate cytotoxic reactive oxygen species upon light activation offers a promising approach to tumor treatment. Recently, BODIPY derivatives have been used for Boron Neutron Capture Therapy (BNCT) for various tumors, and it is a growing research field. Advancements in nanotechnology have allowed the fabrication of BODIPY dye-based nanomedicines, either alone or with the use of metallic nanoparticles as a matrix offering the development of a new class of bioimaging and theragnostic agents. This review also discusses innovative BODIPY-based formulations and strategies that amplify therapeutic efficacy while minimizing adverse effects, underscoring the potential of these dyes as integral components in next-generation diagnostic and therapeutic modalities. By summarizing current research and future perspectives, this review highlights the critical importance of BODIPY dyes in advancing the fields of cellular imaging and treatment methodologies. |
| format | Article |
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| institution | Kabale University |
| issn | 2079-6447 |
| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-aa1295a9ad4a4b73a4a73ccfa9effddf2025-08-20T03:27:15ZengMDPI AGColorants2079-64472025-04-01421310.3390/colorants4020013BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic ApplicationsPanangattukara Prabhakaran Praveen Kumar0Shivanjali Saxena1Rakesh Joshi2Department of Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI 48824, USADARVUN, Punjab 147001, IndiaDARVUN, Punjab 147001, IndiaBODIPY (Boron-Dipyrromethene) dyes have emerged as versatile fluorescent probes in cellular imaging and therapeutic applications owing to their unique chemical properties, including high fluorescence quantum yield, strong extinction coefficients, and remarkable photostability. This review synthesizes the recent advancements in BODIPY dyes, focusing on their deployment in biological imaging and therapy. The exceptional ability of BODIPY dyes to selectively stain cellular structures enables precise visualization of lipids, proteins, and nucleic acids within live and tumor cells, thereby facilitating enhanced understanding of biochemical processes. Moreover, BODIPY derivatives are increasingly utilized in Photodynamic therapy (PDT) and Photothermal therapies (PTT) for targeting cancer cells, where their capability to generate cytotoxic reactive oxygen species upon light activation offers a promising approach to tumor treatment. Recently, BODIPY derivatives have been used for Boron Neutron Capture Therapy (BNCT) for various tumors, and it is a growing research field. Advancements in nanotechnology have allowed the fabrication of BODIPY dye-based nanomedicines, either alone or with the use of metallic nanoparticles as a matrix offering the development of a new class of bioimaging and theragnostic agents. This review also discusses innovative BODIPY-based formulations and strategies that amplify therapeutic efficacy while minimizing adverse effects, underscoring the potential of these dyes as integral components in next-generation diagnostic and therapeutic modalities. By summarizing current research and future perspectives, this review highlights the critical importance of BODIPY dyes in advancing the fields of cellular imaging and treatment methodologies.https://www.mdpi.com/2079-6447/4/2/13BODIPY dyecellular imagingphotodynamic therapyphotothermal therapyboron neutron capture therapy |
| spellingShingle | Panangattukara Prabhakaran Praveen Kumar Shivanjali Saxena Rakesh Joshi BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications Colorants BODIPY dye cellular imaging photodynamic therapy photothermal therapy boron neutron capture therapy |
| title | BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications |
| title_full | BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications |
| title_fullStr | BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications |
| title_full_unstemmed | BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications |
| title_short | BODIPY Dyes: A New Frontier in Cellular Imaging and Theragnostic Applications |
| title_sort | bodipy dyes a new frontier in cellular imaging and theragnostic applications |
| topic | BODIPY dye cellular imaging photodynamic therapy photothermal therapy boron neutron capture therapy |
| url | https://www.mdpi.com/2079-6447/4/2/13 |
| work_keys_str_mv | AT panangattukaraprabhakaranpraveenkumar bodipydyesanewfrontierincellularimagingandtheragnosticapplications AT shivanjalisaxena bodipydyesanewfrontierincellularimagingandtheragnosticapplications AT rakeshjoshi bodipydyesanewfrontierincellularimagingandtheragnosticapplications |