Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review
Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently...
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| Format: | Article |
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Elsevier
2025-03-01
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| Series: | Results in Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259012302500324X |
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| author | Smarika Chauhan Eswar Marcharla Sneha Hariharan Saranya Vinayagam Thanigaivel Sundaram Priya SD Swamynathan Ganesan Maximilian Lackner |
| author_facet | Smarika Chauhan Eswar Marcharla Sneha Hariharan Saranya Vinayagam Thanigaivel Sundaram Priya SD Swamynathan Ganesan Maximilian Lackner |
| author_sort | Smarika Chauhan |
| collection | DOAJ |
| description | Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently encounter problems with poor absorption, toxicity, and a lack of specificity. This review aims to explore the role of nanoparticles in the prognosis and diagnosis of gastric cancer. We have analysed genomic pathways linked with gastric carcinoma and explored the utilisation of nanoparticles for multimodal imaging techniques, precise drug delivery and efficient therapeutic approaches. The use of nanoparticles has the advantage of increasing the effectiveness of treatment outcomes while reducing side effects. Moreover, they enable early detection through highly sensitive imaging techniques, improving the accuracy of diagnosis and disease monitoring. Nanoparticles enhance drug delivery in gastric cancer by enabling precise delivery to tumor sites, improving therapeutic precision, and reducing side effects. They also boost therapy outcomes by overcoming chemotherapy resistance and enabling co-delivery of multiple drugs. Preclinical studies indicate that treatments using nanoparticles demonstrated an increase in early detection and rise in treating diseases compared to traditional therapies. In summary, nanotechnology offers a promising approach in detecting and managing gastric cancer by providing highly efficient and minimally invasive techniques. Integrating nanoparticles into clinical practice can effectively address the limitations of current therapies and significantly improve patient outcomes. |
| format | Article |
| id | doaj-art-aa120649d63c41cfb0c8e66c41417282 |
| institution | Kabale University |
| issn | 2590-1230 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Engineering |
| spelling | doaj-art-aa120649d63c41cfb0c8e66c414172822025-02-08T05:00:59ZengElsevierResults in Engineering2590-12302025-03-0125104238Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A reviewSmarika Chauhan0Eswar Marcharla1Sneha Hariharan2Saranya Vinayagam3Thanigaivel Sundaram4Priya SD5Swamynathan Ganesan6Maximilian Lackner7Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu 603203, IndiaDepartment of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu 603203, IndiaDepartment of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu 603203, IndiaDepartment of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu 602 105, IndiaDepartment of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu 603203, IndiaInstituto de Alta Investigación, Universidad de Tarapacá, Arica 1000000, ChileDepartment of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu 603203, India; Corresponding authors.University of Applied Sciences Technikum Wien, Faculty of Industrial Engineering, Hoechstaedtplatz 6, 1200 Vienna, Austria; Corresponding authors.Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently encounter problems with poor absorption, toxicity, and a lack of specificity. This review aims to explore the role of nanoparticles in the prognosis and diagnosis of gastric cancer. We have analysed genomic pathways linked with gastric carcinoma and explored the utilisation of nanoparticles for multimodal imaging techniques, precise drug delivery and efficient therapeutic approaches. The use of nanoparticles has the advantage of increasing the effectiveness of treatment outcomes while reducing side effects. Moreover, they enable early detection through highly sensitive imaging techniques, improving the accuracy of diagnosis and disease monitoring. Nanoparticles enhance drug delivery in gastric cancer by enabling precise delivery to tumor sites, improving therapeutic precision, and reducing side effects. They also boost therapy outcomes by overcoming chemotherapy resistance and enabling co-delivery of multiple drugs. Preclinical studies indicate that treatments using nanoparticles demonstrated an increase in early detection and rise in treating diseases compared to traditional therapies. In summary, nanotechnology offers a promising approach in detecting and managing gastric cancer by providing highly efficient and minimally invasive techniques. Integrating nanoparticles into clinical practice can effectively address the limitations of current therapies and significantly improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S259012302500324XGastric cancerH. pyloriSignalling pathwaysNanotechnologyTargeted drug deliveryImaging |
| spellingShingle | Smarika Chauhan Eswar Marcharla Sneha Hariharan Saranya Vinayagam Thanigaivel Sundaram Priya SD Swamynathan Ganesan Maximilian Lackner Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review Results in Engineering Gastric cancer H. pylori Signalling pathways Nanotechnology Targeted drug delivery Imaging |
| title | Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review |
| title_full | Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review |
| title_fullStr | Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review |
| title_full_unstemmed | Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review |
| title_short | Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review |
| title_sort | insights into the molecular mechanisms and nanoparticle based therapies for gastric cancer a review |
| topic | Gastric cancer H. pylori Signalling pathways Nanotechnology Targeted drug delivery Imaging |
| url | http://www.sciencedirect.com/science/article/pii/S259012302500324X |
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