CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis

CCR2 recruits monocytes to the lung, while CX3CR1 modulates positioning of CD11cpos cells in the lymph node during pulmonary tuberculosis

ABSTRACT Infection by Mycobacterium tuberculosis (Mtb) continues to cause more than 1 million deaths annually, due to pathogen persistence in lung macrophages and dendritic cells derived from blood monocytes. While the accumulation of monocyte-derived cells in the Mtb-infected lung partially depends...

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Bibliographic Details
Main Authors: Alexander Mohapatra, Brian A. Norris, Zachary Howard, Joel D. Ernst
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
monocytes
immunity
cell trafficking
Online Access:https://journals.asm.org/doi/10.1128/mbio.01237-25
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