Early initiated noradrenaline versus fluid therapy for hypotension and shock in the emergency department (VASOSHOCK): a protocol for a pragmatic, multi-center, superiority, randomized controlled trial

Early initiated noradrenaline versus fluid therapy for hypotension and shock in the emergency department (VASOSHOCK): a protocol for a pragmatic, multi-center, superiority, randomized controlled trial

Abstract Background Shock is a condition with high mortality even with early intervention and treatment. Usual care for shock and hypotension in the Emergency Department (ED) is intravenous fluid resuscitation which can lead to fluid overload and other complications. When fluid therapy fails or risk...

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Main Authors: Lasse Paludan Bentsen, Thomas Strøm, Jakob Lundager Forberg, Gerhard Tiwald, Peter Biesenbach, Malik Kalmriz, Jens Henning Rasmussen, Nikolaj Raaber, Sören Möller, Mette Løkke, Gitte Boier Tygesen, Hanne Nygaard, Josephine Hyldgaard Brok, Julie Westergaard Andersen, Nikolett Bajusz, Mikkel Brabrand
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Subjects:
Shock
Hypotension
Vasopressor
Norepinephrine
Noradrenaline
Fluid therapy
Online Access:https://doi.org/10.1186/s13049-025-01369-4
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