Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2

Bystander monocytic cells drive infection-independent NLRP3 inflammasome response to SARS-CoV-2

ABSTRACT The pathogenesis of COVID-19 is associated with a hyperinflammatory immune response. Monocytes and macrophages play a central role in this hyperinflammatory response to SARS-CoV-2. NLRP3 inflammasome activation has been observed in monocytes of patients with COVID-19, but the mechanism and...

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Bibliographic Details
Main Authors: Leon L. Hsieh, Monika Looney, Alexis Figueroa, Guido Massaccesi, Georgia Stavrakis, Eduardo U. Anaya, Franco R. D'Alessio, Alvaro A. Ordonez, Andrew S. Pekosz, Victor R. DeFilippis, Petros C. Karakousis, Andrew H. Karaba, Andrea L. Cox
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
Subjects:
inflammasome
cytokines
SARS-CoV-2
NLRP3
macrophages
Online Access:https://journals.asm.org/doi/10.1128/mbio.00810-24
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