Revisiting astrocytic calcium signaling in the brain
Astrocytes, characterized by complex spongiform morphology, participate in various physiological processes, and abnormal changes in their calcium (Ca2+) signaling are implicated in central nervous system disorders. However, medications targeting the control of Ca2+ have fallen short of the anticipat...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2024-11-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325824000505 |
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| author | Ying Bai Zhongqiu Zhou Bing Han Xianyuan Xiang Wenhui Huang Honghong Yao |
| author_facet | Ying Bai Zhongqiu Zhou Bing Han Xianyuan Xiang Wenhui Huang Honghong Yao |
| author_sort | Ying Bai |
| collection | DOAJ |
| description | Astrocytes, characterized by complex spongiform morphology, participate in various physiological processes, and abnormal changes in their calcium (Ca2+) signaling are implicated in central nervous system disorders. However, medications targeting the control of Ca2+ have fallen short of the anticipated therapeutic outcomes in clinical applications. This underscores the fact that our comprehension of this intricate regulation of calcium ions remains considerably incomplete. In recent years, with the advancement of Ca2+ labeling, imaging, and analysis techniques, Ca2+ signals have been found to exhibit high specificity at different spatial locations within the intricate structure of astrocytes. This has ushered the study of Ca2+ signaling in astrocytes into a new phase, leading to several groundbreaking research achievements. Despite this, the comprehensive understanding of astrocytic Ca2+ signaling and their implications remains challenging area for future research. |
| format | Article |
| id | doaj-art-aa08f706d7d44671a7238fcc08293398 |
| institution | DOAJ |
| issn | 2667-3258 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj-art-aa08f706d7d44671a7238fcc082933982025-08-20T02:51:46ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582024-11-01461365137410.1016/j.fmre.2023.11.021Revisiting astrocytic calcium signaling in the brainYing Bai0Zhongqiu Zhou1Bing Han2Xianyuan Xiang3Wenhui Huang4Honghong Yao5Department of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing 210009, ChinaDepartment of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing 210009, ChinaShenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaMolecular Physiology, CIPMM, University of Saarland, Homburg 66421, GermanyDepartment of Pharmacology, Jiangsu Provincial Key Laboratory of Critical Care Medicine, School of Medicine, Southeast University, Nanjing 210009, China; Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China; Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China; Corresponding author.Astrocytes, characterized by complex spongiform morphology, participate in various physiological processes, and abnormal changes in their calcium (Ca2+) signaling are implicated in central nervous system disorders. However, medications targeting the control of Ca2+ have fallen short of the anticipated therapeutic outcomes in clinical applications. This underscores the fact that our comprehension of this intricate regulation of calcium ions remains considerably incomplete. In recent years, with the advancement of Ca2+ labeling, imaging, and analysis techniques, Ca2+ signals have been found to exhibit high specificity at different spatial locations within the intricate structure of astrocytes. This has ushered the study of Ca2+ signaling in astrocytes into a new phase, leading to several groundbreaking research achievements. Despite this, the comprehensive understanding of astrocytic Ca2+ signaling and their implications remains challenging area for future research.http://www.sciencedirect.com/science/article/pii/S2667325824000505AstrocyteCa2+ signalingCentral nervous systemSynapseIon channel |
| spellingShingle | Ying Bai Zhongqiu Zhou Bing Han Xianyuan Xiang Wenhui Huang Honghong Yao Revisiting astrocytic calcium signaling in the brain Fundamental Research Astrocyte Ca2+ signaling Central nervous system Synapse Ion channel |
| title | Revisiting astrocytic calcium signaling in the brain |
| title_full | Revisiting astrocytic calcium signaling in the brain |
| title_fullStr | Revisiting astrocytic calcium signaling in the brain |
| title_full_unstemmed | Revisiting astrocytic calcium signaling in the brain |
| title_short | Revisiting astrocytic calcium signaling in the brain |
| title_sort | revisiting astrocytic calcium signaling in the brain |
| topic | Astrocyte Ca2+ signaling Central nervous system Synapse Ion channel |
| url | http://www.sciencedirect.com/science/article/pii/S2667325824000505 |
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