MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions
Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice and is associated with significant morbidity and mortality. Even though catheter ablation has emerged as an available and effective treatment for AF, recurrence remains a significant challenge. This revie...
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MDPI AG
2024-12-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/1/32 |
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| author | Emmanouil P. Vardas Evangelos Oikonomou Panos E. Vardas Dimitris Tousoulis |
| author_facet | Emmanouil P. Vardas Evangelos Oikonomou Panos E. Vardas Dimitris Tousoulis |
| author_sort | Emmanouil P. Vardas |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice and is associated with significant morbidity and mortality. Even though catheter ablation has emerged as an available and effective treatment for AF, recurrence remains a significant challenge. This review presents the existing evidence on the prognostic role of microRNAs (miRNAs) in the prediction of AF recurrence after catheter ablation. We examined studies investigating the association between miRNA expression and post-ablation AF recurrence. Multiple miRNAs have been highlighted as potential biomarkers, which are involved in pathophysiological processes such as atrial remodeling, fibrosis, and inflammation. Despite some promising results, there has been significant heterogeneity across the studies. In this review, we demonstrate the potential miRNAs that can be routinely used as biomarkers of AF recurrence, and we identify areas that require further research to validate their clinical utility. |
| format | Article |
| id | doaj-art-aa06ce4ebb7d4c6a97ffab55224d8b10 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-aa06ce4ebb7d4c6a97ffab55224d8b102025-01-24T13:23:47ZengMDPI AGBiomedicines2227-90592024-12-011313210.3390/biomedicines13010032MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future DirectionsEmmanouil P. Vardas0Evangelos Oikonomou1Panos E. Vardas2Dimitris Tousoulis31st Cardiology Department, General Hospital of Athens “Hippokration”, University of Athens Medical School, 11528 Athens, Greece3rd Cardiology Department, Sotiria Regional Hospital for Chest Diseases, University of Athens Medical School, 11527 Athens, GreeceBiomedical Research Foundation Academy of Athens, Heart Sector, Hygeia Hospitals Group, Attica, 15123 Athens, Greece1st Cardiology Department, General Hospital of Athens “Hippokration”, University of Athens Medical School, 11528 Athens, GreeceAtrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice and is associated with significant morbidity and mortality. Even though catheter ablation has emerged as an available and effective treatment for AF, recurrence remains a significant challenge. This review presents the existing evidence on the prognostic role of microRNAs (miRNAs) in the prediction of AF recurrence after catheter ablation. We examined studies investigating the association between miRNA expression and post-ablation AF recurrence. Multiple miRNAs have been highlighted as potential biomarkers, which are involved in pathophysiological processes such as atrial remodeling, fibrosis, and inflammation. Despite some promising results, there has been significant heterogeneity across the studies. In this review, we demonstrate the potential miRNAs that can be routinely used as biomarkers of AF recurrence, and we identify areas that require further research to validate their clinical utility.https://www.mdpi.com/2227-9059/13/1/32atrial fibrillationfibrosisinflammationelectrical remodelingmicroRNArecurrence |
| spellingShingle | Emmanouil P. Vardas Evangelos Oikonomou Panos E. Vardas Dimitris Tousoulis MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions Biomedicines atrial fibrillation fibrosis inflammation electrical remodeling microRNA recurrence |
| title | MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions |
| title_full | MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions |
| title_fullStr | MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions |
| title_full_unstemmed | MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions |
| title_short | MicroRNAs as Prognostic Biomarkers for Atrial Fibrillation Recurrence After Catheter Ablation: Current Evidence and Future Directions |
| title_sort | micrornas as prognostic biomarkers for atrial fibrillation recurrence after catheter ablation current evidence and future directions |
| topic | atrial fibrillation fibrosis inflammation electrical remodeling microRNA recurrence |
| url | https://www.mdpi.com/2227-9059/13/1/32 |
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