Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices

Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferat...

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Main Authors: Andréanne Durivage, Geneviève Le Templier, Annabelle Cumyn, Nadine Sauvé
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Case Reports in Obstetrics and Gynecology
Online Access:http://dx.doi.org/10.1155/2019/5702983
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author Andréanne Durivage
Geneviève Le Templier
Annabelle Cumyn
Nadine Sauvé
author_facet Andréanne Durivage
Geneviève Le Templier
Annabelle Cumyn
Nadine Sauvé
author_sort Andréanne Durivage
collection DOAJ
description Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. These conditions put pregnant women at increased risk of vascular complications, including venous thrombosis, occlusion of the placental circulation, and variceal bleeding. In this report, we present a 36-year-old pregnant woman with chronic, anticoagulated EHPVO secondary to latent MPN who developed severe intrauterine growth restriction and had cesarean section at 32+1 weeks for increased umbilical doppler resistance and breech presentation. The article will emphasize outcome and management of pregnancies complicated by chronic EHPVO, portal hypertension, and MPN.
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publishDate 2019-01-01
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series Case Reports in Obstetrics and Gynecology
spelling doaj-art-aa04faaec1254a9b83e9ee041b9cf1522025-08-20T02:20:41ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922019-01-01201910.1155/2019/57029835702983Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric VaricesAndréanne Durivage0Geneviève Le Templier1Annabelle Cumyn2Nadine Sauvé3Department of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, CanadaDepartment of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, CanadaDepartment of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, CanadaDepartment of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, CanadaExtra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. These conditions put pregnant women at increased risk of vascular complications, including venous thrombosis, occlusion of the placental circulation, and variceal bleeding. In this report, we present a 36-year-old pregnant woman with chronic, anticoagulated EHPVO secondary to latent MPN who developed severe intrauterine growth restriction and had cesarean section at 32+1 weeks for increased umbilical doppler resistance and breech presentation. The article will emphasize outcome and management of pregnancies complicated by chronic EHPVO, portal hypertension, and MPN.http://dx.doi.org/10.1155/2019/5702983
spellingShingle Andréanne Durivage
Geneviève Le Templier
Annabelle Cumyn
Nadine Sauvé
Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
Case Reports in Obstetrics and Gynecology
title Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
title_full Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
title_fullStr Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
title_full_unstemmed Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
title_short Pregnancy in a Woman with Latent Myeloproliferative Neoplasm Induced Chronic Portal Vein Thrombosis, Portal Cavernoma, and Gastric Varices
title_sort pregnancy in a woman with latent myeloproliferative neoplasm induced chronic portal vein thrombosis portal cavernoma and gastric varices
url http://dx.doi.org/10.1155/2019/5702983
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