Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity

Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity

Insulin resistance (IR) is an early marker of cardiometabolic deterioration which may develop heterogeneously in key metabolic organs, including the liver (LIR) and skeletal muscle (MIR). This tissue-specific IR is characterized by distinct metabolic signatures, but the role of the gut microbiota in...

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Main Authors: Kelly M. Jardon, Alexander Umanets, Anouk Gijbels, Inez Trouwborst, Gabby B. Hul, Els Siebelink, Lars M.M. Vliex, Jacco J.A.J. Bastings, Rosa Argamasilla, Elodie Chenal, Koen Venema, Lydia A. Afman, Gijs H. Goossens, Ellen E. Blaak
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Tissue-specific insulin resistance: obesity
gut microbiota
gut metabolites
GLP-1
metabolic subtyping
precision health
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2501185
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2501185

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