Five questions on the cell-to-cell movement of Orthotospoviruses
Plant viruses employ Movement proteins (MP) for their cell to cell spread through plasmodesmata (PD). MP modifies the PD and increases its size exclusion limit (SEL). However, the mechanism by which MPs are targeted to the PD is still unresolved and there is a lack of consensus owing to limited stud...
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Elsevier
2024-01-01
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| Series: | BBA Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160324000127 |
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| author | Pratibha Singh Rishi Raj H.S. Savithri |
| author_facet | Pratibha Singh Rishi Raj H.S. Savithri |
| author_sort | Pratibha Singh |
| collection | DOAJ |
| description | Plant viruses employ Movement proteins (MP) for their cell to cell spread through plasmodesmata (PD). MP modifies the PD and increases its size exclusion limit (SEL). However, the mechanism by which MPs are targeted to the PD is still unresolved and there is a lack of consensus owing to limited studies on their biochemical and structural characters. The non structural protein m (NSm) functions as the MP in Orthotospoviruses. Tospoviral NSm associate with ER membrane. They also form tubules in protoplasts. Groundnut bud necrosis virus (GBNV), a tospovirus, infects several crop plants throughout India and is economically very important. GBNV NSm associates with the membrane strongly via the C-terminal coiled-coil domain, modifies the membrane and causes vesicle fusion in vitro and remodels the ER network into vesicles in vivo. These vesicles are in contrast to the tubules formed by other related tospovirus in cells lacking cell wall. In this review, five important questions on the cell-to-cell movement of tospoviruses have been addressed and based on the various reports, a plausible model on the cell-to-cell movement of Orthotospoviruses is presented. |
| format | Article |
| id | doaj-art-aa00ce8d0d804dc5bbf627d908234b02 |
| institution | OA Journals |
| issn | 2667-1603 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
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| series | BBA Advances |
| spelling | doaj-art-aa00ce8d0d804dc5bbf627d908234b022025-08-20T01:56:49ZengElsevierBBA Advances2667-16032024-01-01610012410.1016/j.bbadva.2024.100124Five questions on the cell-to-cell movement of OrthotospovirusesPratibha Singh0Rishi Raj1H.S. Savithri2Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar 845401, India; Corresponding author at: Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar 845401.Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar 845401, IndiaDepartment of Biochemistry, Indian Institute of Science, Bangalore 560012, IndiaPlant viruses employ Movement proteins (MP) for their cell to cell spread through plasmodesmata (PD). MP modifies the PD and increases its size exclusion limit (SEL). However, the mechanism by which MPs are targeted to the PD is still unresolved and there is a lack of consensus owing to limited studies on their biochemical and structural characters. The non structural protein m (NSm) functions as the MP in Orthotospoviruses. Tospoviral NSm associate with ER membrane. They also form tubules in protoplasts. Groundnut bud necrosis virus (GBNV), a tospovirus, infects several crop plants throughout India and is economically very important. GBNV NSm associates with the membrane strongly via the C-terminal coiled-coil domain, modifies the membrane and causes vesicle fusion in vitro and remodels the ER network into vesicles in vivo. These vesicles are in contrast to the tubules formed by other related tospovirus in cells lacking cell wall. In this review, five important questions on the cell-to-cell movement of tospoviruses have been addressed and based on the various reports, a plausible model on the cell-to-cell movement of Orthotospoviruses is presented.http://www.sciencedirect.com/science/article/pii/S2667160324000127Plant virusNegative strand RNA virusMovement proteinPlasmodesmataProtein trafficking |
| spellingShingle | Pratibha Singh Rishi Raj H.S. Savithri Five questions on the cell-to-cell movement of Orthotospoviruses BBA Advances Plant virus Negative strand RNA virus Movement protein Plasmodesmata Protein trafficking |
| title | Five questions on the cell-to-cell movement of Orthotospoviruses |
| title_full | Five questions on the cell-to-cell movement of Orthotospoviruses |
| title_fullStr | Five questions on the cell-to-cell movement of Orthotospoviruses |
| title_full_unstemmed | Five questions on the cell-to-cell movement of Orthotospoviruses |
| title_short | Five questions on the cell-to-cell movement of Orthotospoviruses |
| title_sort | five questions on the cell to cell movement of orthotospoviruses |
| topic | Plant virus Negative strand RNA virus Movement protein Plasmodesmata Protein trafficking |
| url | http://www.sciencedirect.com/science/article/pii/S2667160324000127 |
| work_keys_str_mv | AT pratibhasingh fivequestionsonthecelltocellmovementoforthotospoviruses AT rishiraj fivequestionsonthecelltocellmovementoforthotospoviruses AT hssavithri fivequestionsonthecelltocellmovementoforthotospoviruses |