Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design
BackgroundCardiovascular (CV) disease is the leading cause of death in women. Although 80% of CV disease events can be prevented, mortality is projected to increase, particularly in young women.ObjectivesTo promote CV health in women and encourage appropriate lifestyle changes by increasing awarenes...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1535827/full |
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| author | Samantha Wasniewski Samantha Wasniewski Rafaella Kfouri Da Silva Rafaella Kfouri Da Silva Sofía Capdeville Sofía Capdeville Isabel Rivera Molina Elena Virosta Carolina Ortiz Cortés Pablo Díez-Villanueva Pablo Díez-Villanueva Antonio Adeba Marta Ruiz Lera Lucía Muñoz David Alonso Eva García Ruth Echeverría Ruth Echeverría Rocío Tarifa Alessia Ferrarini Josué Pagán Josué Pagán Jose Luis Ayala Jose Luis Ayala Jorge Solis Jorge Solis Jorge Solis Jorge Solis Malissa Wood Blanca Miranda Luis Rodríguez Padial Leticia Fernández-Friera Leticia Fernández-Friera Leticia Fernández-Friera |
| author_facet | Samantha Wasniewski Samantha Wasniewski Rafaella Kfouri Da Silva Rafaella Kfouri Da Silva Sofía Capdeville Sofía Capdeville Isabel Rivera Molina Elena Virosta Carolina Ortiz Cortés Pablo Díez-Villanueva Pablo Díez-Villanueva Antonio Adeba Marta Ruiz Lera Lucía Muñoz David Alonso Eva García Ruth Echeverría Ruth Echeverría Rocío Tarifa Alessia Ferrarini Josué Pagán Josué Pagán Jose Luis Ayala Jose Luis Ayala Jorge Solis Jorge Solis Jorge Solis Jorge Solis Malissa Wood Blanca Miranda Luis Rodríguez Padial Leticia Fernández-Friera Leticia Fernández-Friera Leticia Fernández-Friera |
| author_sort | Samantha Wasniewski |
| collection | DOAJ |
| description | BackgroundCardiovascular (CV) disease is the leading cause of death in women. Although 80% of CV disease events can be prevented, mortality is projected to increase, particularly in young women.ObjectivesTo promote CV health in women and encourage appropriate lifestyle changes by increasing awareness through vascular ultrasound imaging.MethodsWAKE UP is a prospective case-control study in a target population of 720 asymptomatic women, aged 40–70 years with ≥1 major CV risk factor (RF). Participants will attend a baseline visit and follow-up visits at 6 and 12-months. Each visit will include the assessment of traditional and non-traditional risk factors (age, blood pressure, weight, smoking, diet, physical activity, psychosocial aspects, reproductive factors, family lifestyle), CV risk scores [Fuster-BEWAT Score (FBS) and SCORE], perception of CV disease risk, blood sampling of hormones, lipids, glycemic metabolism, inflammation parameters and omics. At baseline visit, women will be randomized to undergo 2D/3D/strain vascular ultrasound (360 with imaging vs. 360 age- and RF-matched controls without imaging). Main outcomes will include changes from baseline to follow-up in overall knowledge, attitudes, and FBS.ConclusionsWAKE UP trial aims to raise awareness about womeńs CV disease and promote lifestyle changes. Imaging can play a key role by revealing the presence of atherosclerotic plaques in a directly relatable way and thus, larger effects are anticipated in women with plaques. WAKE UP can significantly impact CV prevention by involving innovative actions addressing a major public health need and by fostering complementary and synergistic actions. |
| format | Article |
| id | doaj-art-a9fdf65b7f6143e98c6698f205542e8a |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-a9fdf65b7f6143e98c6698f205542e8a2025-08-20T03:42:03ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-03-011210.3389/fcvm.2025.15358271535827Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and designSamantha Wasniewski0Samantha Wasniewski1Rafaella Kfouri Da Silva2Rafaella Kfouri Da Silva3Sofía Capdeville4Sofía Capdeville5Isabel Rivera Molina6Elena Virosta7Carolina Ortiz Cortés8Pablo Díez-Villanueva9Pablo Díez-Villanueva10Antonio Adeba11Marta Ruiz Lera12Lucía Muñoz13David Alonso14Eva García15Ruth Echeverría16Ruth Echeverría17Rocío Tarifa18Alessia Ferrarini19Josué Pagán20Josué Pagán21Jose Luis Ayala22Jose Luis Ayala23Jorge Solis24Jorge Solis25Jorge Solis26Jorge Solis27Malissa Wood28Blanca Miranda29Luis Rodríguez Padial30Leticia Fernández-Friera31Leticia Fernández-Friera32Leticia Fernández-Friera33HM CIEC MADRID (Centro Integral de Enfermedades Cardiovasculares), Hospital Universitario HM Montepríncipe, HM Hospitales, Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Instituto de Investigación Sanitaria HM Hospitales, Madrid, SpainAtria Clinic, Madrid, SpainAtria Clinic, Madrid, SpainInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, SpainAtria Clinic, Madrid, SpainInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, SpainHM CIEC MADRID (Centro Integral de Enfermedades Cardiovasculares), Hospital Universitario HM Montepríncipe, HM Hospitales, Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Instituto de Investigación Sanitaria HM Hospitales, Madrid, SpainHM CIEC MADRID (Centro Integral de Enfermedades Cardiovasculares), Hospital Universitario HM Montepríncipe, HM Hospitales, Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Instituto de Investigación Sanitaria HM Hospitales, Madrid, SpainHospital Universitario Fundación de Alcorcón, Madrid, SpainAtria Clinic, Madrid, SpainHospital Universitario La Princesa, Madrid, SpainHospital Universitario Cabueñes, Asturias, SpainHospital Universitario Marqués de Valdecilla, Santander, SpainHospital Universitario Marqués de Valdecilla, Santander, SpainHospital Universitario HM Regla, León, SpainComplejo Hospitalario de Toledo, Castilla La Mancha, SpainInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain0Fundación Para la Investigación Biomédica del Hospital Universitario 12 de Octubre (FIBH12O), Madrid, Spain1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain2Electronic Engineering Department, Universidad Politécnica de Madrid, Madrid, Spain3Center for Computational Simulation, Universidad Politécnica de Madrid, Boadilla del Monte, Spain3Center for Computational Simulation, Universidad Politécnica de Madrid, Boadilla del Monte, Spain4Department of Computer Architecture and Automation, Universidad Complutense de Madrid, Madrid, SpainAtria Clinic, Madrid, SpainInstituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain5Hospital Universitario 12 de Octubre, Madrid, Spain6CIBER de Investigaciones Cardiovasculares (CIBERCV), Madrid, Spain7Department of Cardiology, Lee Health Heart Institute, Fort Myers, FL, United States8Sociedad Española de Cardiología, Madrid, SpainComplejo Hospitalario de Toledo, Castilla La Mancha, SpainHM CIEC MADRID (Centro Integral de Enfermedades Cardiovasculares), Hospital Universitario HM Montepríncipe, HM Hospitales, Facultad HM de Ciencias de la Salud de la Universidad Camilo José Cela, Instituto de Investigación Sanitaria HM Hospitales, Madrid, SpainAtria Clinic, Madrid, Spain6CIBER de Investigaciones Cardiovasculares (CIBERCV), Madrid, SpainBackgroundCardiovascular (CV) disease is the leading cause of death in women. Although 80% of CV disease events can be prevented, mortality is projected to increase, particularly in young women.ObjectivesTo promote CV health in women and encourage appropriate lifestyle changes by increasing awareness through vascular ultrasound imaging.MethodsWAKE UP is a prospective case-control study in a target population of 720 asymptomatic women, aged 40–70 years with ≥1 major CV risk factor (RF). Participants will attend a baseline visit and follow-up visits at 6 and 12-months. Each visit will include the assessment of traditional and non-traditional risk factors (age, blood pressure, weight, smoking, diet, physical activity, psychosocial aspects, reproductive factors, family lifestyle), CV risk scores [Fuster-BEWAT Score (FBS) and SCORE], perception of CV disease risk, blood sampling of hormones, lipids, glycemic metabolism, inflammation parameters and omics. At baseline visit, women will be randomized to undergo 2D/3D/strain vascular ultrasound (360 with imaging vs. 360 age- and RF-matched controls without imaging). Main outcomes will include changes from baseline to follow-up in overall knowledge, attitudes, and FBS.ConclusionsWAKE UP trial aims to raise awareness about womeńs CV disease and promote lifestyle changes. Imaging can play a key role by revealing the presence of atherosclerotic plaques in a directly relatable way and thus, larger effects are anticipated in women with plaques. WAKE UP can significantly impact CV prevention by involving innovative actions addressing a major public health need and by fostering complementary and synergistic actions.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1535827/fullwomen's healthcardiovascular disease preventionvascular ultrasoundcardiovascular risklifestyle |
| spellingShingle | Samantha Wasniewski Samantha Wasniewski Rafaella Kfouri Da Silva Rafaella Kfouri Da Silva Sofía Capdeville Sofía Capdeville Isabel Rivera Molina Elena Virosta Carolina Ortiz Cortés Pablo Díez-Villanueva Pablo Díez-Villanueva Antonio Adeba Marta Ruiz Lera Lucía Muñoz David Alonso Eva García Ruth Echeverría Ruth Echeverría Rocío Tarifa Alessia Ferrarini Josué Pagán Josué Pagán Jose Luis Ayala Jose Luis Ayala Jorge Solis Jorge Solis Jorge Solis Jorge Solis Malissa Wood Blanca Miranda Luis Rodríguez Padial Leticia Fernández-Friera Leticia Fernández-Friera Leticia Fernández-Friera Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design Frontiers in Cardiovascular Medicine women's health cardiovascular disease prevention vascular ultrasound cardiovascular risk lifestyle |
| title | Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design |
| title_full | Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design |
| title_fullStr | Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design |
| title_full_unstemmed | Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design |
| title_short | Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design |
| title_sort | women s health an imaging based cardiovascular risk reduction program wake up study rationale and design |
| topic | women's health cardiovascular disease prevention vascular ultrasound cardiovascular risk lifestyle |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1535827/full |
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