DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer
New reliable approaches to stratify patients with endometrial cancer into risk categories are highly needed. We have recently demonstrated that DJ-1 is overexpressed in endometrial cancer, showing significantly higher levels both in serum and tissue of patients with high-risk endometrial cancer comp...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-05-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317705746 |
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| author | Annalisa Di Cello Maddalena Di Sanzo Francesca Marta Perrone Gianluca Santamaria Erika Rania Elvira Angotti Roberta Venturella Serafina Mancuso Fulvio Zullo Giovanni Cuda Francesco Costanzo |
| author_facet | Annalisa Di Cello Maddalena Di Sanzo Francesca Marta Perrone Gianluca Santamaria Erika Rania Elvira Angotti Roberta Venturella Serafina Mancuso Fulvio Zullo Giovanni Cuda Francesco Costanzo |
| author_sort | Annalisa Di Cello |
| collection | DOAJ |
| description | New reliable approaches to stratify patients with endometrial cancer into risk categories are highly needed. We have recently demonstrated that DJ-1 is overexpressed in endometrial cancer, showing significantly higher levels both in serum and tissue of patients with high-risk endometrial cancer compared with low-risk endometrial cancer. In this experimental study, we further extended our observation, evaluating the role of DJ-1 as an accurate serum biomarker for high-risk endometrial cancer. A total of 101 endometrial cancer patients and 44 healthy subjects were prospectively recruited. DJ-1 serum levels were evaluated comparing cases and controls and, among endometrial cancer patients, between high- and low-risk patients. The results demonstrate that DJ-1 levels are significantly higher in cases versus controls and in high- versus low-risk patients. The receiver operating characteristic curve analysis shows that DJ-1 has a very good diagnostic accuracy in discriminating endometrial cancer patients versus controls and an excellent accuracy in distinguishing, among endometrial cancer patients, low- from high-risk cases. DJ-1 sensitivity and specificity are the highest when high- and low-risk patients are compared, reaching the value of 95% and 99%, respectively. Moreover, DJ-1 serum levels seem to be correlated with worsening of the endometrial cancer grade and histotype, making it a reliable tool in the preoperative decision-making process. |
| format | Article |
| id | doaj-art-a9fd269d7d6046faa301a7fc960d8669 |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-a9fd269d7d6046faa301a7fc960d86692025-08-20T03:34:53ZengSAGE PublishingTumor Biology1423-03802017-05-013910.1177/1010428317705746DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancerAnnalisa Di Cello0Maddalena Di Sanzo1Francesca Marta Perrone2Gianluca Santamaria3Erika Rania4Elvira Angotti5Roberta Venturella6Serafina Mancuso7Fulvio Zullo8Giovanni Cuda9Francesco Costanzo10Unit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyUnit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyLaboratory of Clinical Biochemistry, AOU Mater Domini, Catanzaro, ItalyUnit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyLaboratory of Clinical Biochemistry, AOU Mater Domini, Catanzaro, ItalyUnit of Obstetrics and Gynaecology, Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, ItalyNew reliable approaches to stratify patients with endometrial cancer into risk categories are highly needed. We have recently demonstrated that DJ-1 is overexpressed in endometrial cancer, showing significantly higher levels both in serum and tissue of patients with high-risk endometrial cancer compared with low-risk endometrial cancer. In this experimental study, we further extended our observation, evaluating the role of DJ-1 as an accurate serum biomarker for high-risk endometrial cancer. A total of 101 endometrial cancer patients and 44 healthy subjects were prospectively recruited. DJ-1 serum levels were evaluated comparing cases and controls and, among endometrial cancer patients, between high- and low-risk patients. The results demonstrate that DJ-1 levels are significantly higher in cases versus controls and in high- versus low-risk patients. The receiver operating characteristic curve analysis shows that DJ-1 has a very good diagnostic accuracy in discriminating endometrial cancer patients versus controls and an excellent accuracy in distinguishing, among endometrial cancer patients, low- from high-risk cases. DJ-1 sensitivity and specificity are the highest when high- and low-risk patients are compared, reaching the value of 95% and 99%, respectively. Moreover, DJ-1 serum levels seem to be correlated with worsening of the endometrial cancer grade and histotype, making it a reliable tool in the preoperative decision-making process.https://doi.org/10.1177/1010428317705746 |
| spellingShingle | Annalisa Di Cello Maddalena Di Sanzo Francesca Marta Perrone Gianluca Santamaria Erika Rania Elvira Angotti Roberta Venturella Serafina Mancuso Fulvio Zullo Giovanni Cuda Francesco Costanzo DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer Tumor Biology |
| title | DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer |
| title_full | DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer |
| title_fullStr | DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer |
| title_full_unstemmed | DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer |
| title_short | DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer |
| title_sort | dj 1 is a reliable serum biomarker for discriminating high risk endometrial cancer |
| url | https://doi.org/10.1177/1010428317705746 |
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