Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction
The aim of the research was to study antioxidant activity and protective potential of new phenol-containing thioacetyl derivatives of D- and L-prolines as potential agents on beluga sperm and survival in the early stages of ontogeny of bester (Huso x Acipenser ruthenus) development. The study indica...
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| Language: | English |
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KeAi Communications Co., Ltd.
2025-07-01
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| Series: | Aquaculture and Fisheries |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468550X24000510 |
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| author | Victoria P. Osipova Margarita N. Kolyada Maria A. Polovinkina Anastasia D. Kolumbet Vadim A. Grigoriev Elena N. Ponomareva Yuri T. Pimenov Konstantin V. Kudryavtsev |
| author_facet | Victoria P. Osipova Margarita N. Kolyada Maria A. Polovinkina Anastasia D. Kolumbet Vadim A. Grigoriev Elena N. Ponomareva Yuri T. Pimenov Konstantin V. Kudryavtsev |
| author_sort | Victoria P. Osipova |
| collection | DOAJ |
| description | The aim of the research was to study antioxidant activity and protective potential of new phenol-containing thioacetyl derivatives of D- and L-prolines as potential agents on beluga sperm and survival in the early stages of ontogeny of bester (Huso x Acipenser ruthenus) development. The study indicated that both enantiomers demonstrated the equal scavenging activity towards DPPH•, ABTS•+, O2•–, H2O2 and NO, and that the activity towards all of these radicals, with the exception of nitric oxide, exceeded the activity of BHT. No significant differences were registered between the enantiomers in the inhibition of long-term lipid peroxidation of beluga sperm in vitro. The enantiomers revealed the opposite effect on the motility duration time of beluga spermatozoa, the rate of their fertilization, and survival at the early stages of bester ontogeny. Application of the L-proline derivative for the beluga sperm treatment resulted in the increase of the total period of movement of beluga sperm cells, the raise of the fertility of sterlet eggs and the survival of bester offspring at the prelarval stage, which led to an increase in the number of produced larvae. The introduction of the D-proline derivative or BHT decreased the motility duration time of beluga sperm, the fertility of sterlet eggs and the survival of offspring at the prolarval stage, which led to a decrease in the number of obtained larvae. |
| format | Article |
| id | doaj-art-a9ecfd2cfa4748e8a8b60673f9fd0036 |
| institution | Kabale University |
| issn | 2468-550X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Aquaculture and Fisheries |
| spelling | doaj-art-a9ecfd2cfa4748e8a8b60673f9fd00362025-08-20T03:27:57ZengKeAi Communications Co., Ltd.Aquaculture and Fisheries2468-550X2025-07-0110470571410.1016/j.aaf.2024.03.010Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproductionVictoria P. Osipova0Margarita N. Kolyada1Maria A. Polovinkina2Anastasia D. Kolumbet3Vadim A. Grigoriev4Elena N. Ponomareva5Yuri T. Pimenov6Konstantin V. Kudryavtsev7Southern Scientific Centre of Russian Academy of Science, Rostov-on-Don, 344006, Russia; Corresponding author.Southern Scientific Centre of Russian Academy of Science, Rostov-on-Don, 344006, RussiaSouthern Scientific Centre of Russian Academy of Science, Rostov-on-Don, 344006, RussiaDepartment of Chemistry, Astrakhan State Technical University, Astrakhan, 414056, RussiaSouthern Scientific Centre of Russian Academy of Science, Rostov-on-Don, 344006, RussiaSouthern Scientific Centre of Russian Academy of Science, Rostov-on-Don, 344006, RussiaDepartment of Chemistry, Astrakhan State Technical University, Astrakhan, 414056, RussiaVreden National Medical Research Center of Traumatology and Orthopedics, St. Petersburg, 195427, Russia; Corresponding author.The aim of the research was to study antioxidant activity and protective potential of new phenol-containing thioacetyl derivatives of D- and L-prolines as potential agents on beluga sperm and survival in the early stages of ontogeny of bester (Huso x Acipenser ruthenus) development. The study indicated that both enantiomers demonstrated the equal scavenging activity towards DPPH•, ABTS•+, O2•–, H2O2 and NO, and that the activity towards all of these radicals, with the exception of nitric oxide, exceeded the activity of BHT. No significant differences were registered between the enantiomers in the inhibition of long-term lipid peroxidation of beluga sperm in vitro. The enantiomers revealed the opposite effect on the motility duration time of beluga spermatozoa, the rate of their fertilization, and survival at the early stages of bester ontogeny. Application of the L-proline derivative for the beluga sperm treatment resulted in the increase of the total period of movement of beluga sperm cells, the raise of the fertility of sterlet eggs and the survival of bester offspring at the prelarval stage, which led to an increase in the number of produced larvae. The introduction of the D-proline derivative or BHT decreased the motility duration time of beluga sperm, the fertility of sterlet eggs and the survival of offspring at the prolarval stage, which led to a decrease in the number of obtained larvae.http://www.sciencedirect.com/science/article/pii/S2468550X24000510Antioxidant activityProline derivativeBHTBeluga spermFertilityBester |
| spellingShingle | Victoria P. Osipova Margarita N. Kolyada Maria A. Polovinkina Anastasia D. Kolumbet Vadim A. Grigoriev Elena N. Ponomareva Yuri T. Pimenov Konstantin V. Kudryavtsev Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction Aquaculture and Fisheries Antioxidant activity Proline derivative BHT Beluga sperm Fertility Bester |
| title | Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| title_full | Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| title_fullStr | Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| title_full_unstemmed | Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| title_short | Chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| title_sort | chiral thioacetyl derivatives of proline as novel potential agents for beluga reproduction |
| topic | Antioxidant activity Proline derivative BHT Beluga sperm Fertility Bester |
| url | http://www.sciencedirect.com/science/article/pii/S2468550X24000510 |
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