Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation

Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation

Abstract Background Perioperative neurocognitive disorder (PND), a prevalent neurological complication in elderly patients following anesthesia and surgery, has recently been linked to ferroptosis as a central pathogenic mechanism. Sirtuin-3 (SIRT3), a NAD+-dependent deacetylase, exhibits neuroprote...

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Bibliographic Details
Main Authors: Lian Zeng, Pengchao Hu, Xuan Wang, Xudong Ding, Qingsong Wang, Li Luo, Yu Zhang, Mingyue Li, Yilin Zhao, Shiyong Li, Ailin Luo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Nanobiotechnology
Subjects:
Perioperative neurocognitive disorder
Ferroptosis
SIRT3
Honokiol
GPX4
Online Access:https://doi.org/10.1186/s12951-025-03502-y
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