Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research)
Aim. These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).General provisions. GERD is the most common reason for patients to visit clinics. Th...
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Gastro LLC
2024-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1395 |
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| author | V. T. Ivashkin A. S. Trukhmanov I. V. Maev O. M. Drapkina M. A. Livzan A. I. Martynov T. L. Lapina A. V. Paraskevova D. N. Andreev O. P. Alexeeva S. A. Alekseenko A. Yu. Baranovsky O. V. Zayratyants O. Yu. Zolnikova O. B. Dronova I. L. Kliaritskaia N. V. Korochanskaya Yu. A. Kucheryavyy S. N. Mammaev M. F. Osipenko S. S. Pirogov E. A. Poluektova D. E. Rumyantseva R. G. Sayfutdinov O. A. Storonova Yu. P. Uspenskiy I. B. Khlynov V. V. Tsukanov A. A. Sheptulin |
| author_facet | V. T. Ivashkin A. S. Trukhmanov I. V. Maev O. M. Drapkina M. A. Livzan A. I. Martynov T. L. Lapina A. V. Paraskevova D. N. Andreev O. P. Alexeeva S. A. Alekseenko A. Yu. Baranovsky O. V. Zayratyants O. Yu. Zolnikova O. B. Dronova I. L. Kliaritskaia N. V. Korochanskaya Yu. A. Kucheryavyy S. N. Mammaev M. F. Osipenko S. S. Pirogov E. A. Poluektova D. E. Rumyantseva R. G. Sayfutdinov O. A. Storonova Yu. P. Uspenskiy I. B. Khlynov V. V. Tsukanov A. A. Sheptulin |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim. These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).General provisions. GERD is the most common reason for patients to visit clinics. There are esophageal and extraesophageal manifestations of GERD. Patients' complaints of heartburn and regurgitation remain the most sensitive and specific clinical manifestations of GERD. The diagnosis of GERD is established on the basis of anamnestic data, instrumental examination (detection of reflux esophagitis during upper gastrointestinal endoscopy, detection of pathological gastroesophageal reflux with 24-hour pH-metry or/and 24-hour pH-impedance monitoring). Patients with suspected GERD and the absence of erosive and ulcerative changes in the mucous membrane of the esophagus or the presence of erosive esophagitis of Grade A according to Los Angeles Classification of Gastroesophageal Reflux Disease are recommended to conduct 24-hour pH-metry on PPI off to exclude or confirm the diagnosis of GERD. Patients with extraesophageal manifestations of GERD without classic symptoms (heartburn, regurgitation) are recommended to undergo 24-hour pH-impedance monitoring with discontinuation of proton pump inhibitor therapy. When deciding on surgical treatment, all patients need to perform high-resolution esophageal manometry and 24-hour pH-impedance monitoring. Complications of GERD include bleeding, strictures, Barrett’s esophagus and esophageal adenocarcinoma. The main groups of medications used in the treatment of GERD are proton pump inhibitors (PPIs), potassium-competitive acid blockers (P-CABs), alginates, antacids, and prokinetics. PPIs are the drugs of choice in the treatment of both symptoms of gastroesophageal reflux disease and existing erosive esophagitis. Combination therapy Rebamipide with PPIs increases the effectiveness of relief of GERD symptoms, as well as reduces the frequency of relapses.Conclusion. These clinical recommendations will improve the quality of medical care for patients with GERD. |
| format | Article |
| id | doaj-art-a9dee8cd0e9c4ee18756553ef7ff9e01 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-a9dee8cd0e9c4ee18756553ef7ff9e012025-02-10T16:14:40ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-12-0134511113510.22416/1382-4376-2024-34-5-111-1351082Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research)V. T. Ivashkin0A. S. Trukhmanov1I. V. Maev2O. M. Drapkina3M. A. Livzan4A. I. Martynov5T. L. Lapina6A. V. Paraskevova7D. N. Andreev8O. P. Alexeeva9S. A. Alekseenko10A. Yu. Baranovsky11O. V. Zayratyants12O. Yu. Zolnikova13O. B. Dronova14I. L. Kliaritskaia15N. V. Korochanskaya16Yu. A. Kucheryavyy17S. N. Mammaev18M. F. Osipenko19S. S. Pirogov20E. A. Poluektova21D. E. Rumyantseva22R. G. Sayfutdinov23O. A. Storonova24Yu. P. Uspenskiy25I. B. Khlynov26V. V. Tsukanov27A. A. Sheptulin28I.M. Sechenov First Moscow State University (Sechenov University)I.M. Sechenov First Moscow State University (Sechenov University)Russian University of MedicineNational Research Center for Therapy and Preventive MedicineOmsk State Medical UniversityRussian University of MedicineI.M. Sechenov First Moscow State University (Sechenov University)I.M. Sechenov First Moscow State University (Sechenov University)Russian University of MedicineNizhny Novgorod Regional Clinical Hospital named after N.A. SemashkoFar-Eastern State Medical UniversitySaint Petersburg UniversityRussian University of MedicineI.M. Sechenov First Moscow State University (Sechenov University)Orenburg State Medical UniversityV.I. Vernadsky Crimean Federal UniversityKuban State Medical UniversityIlyinskaya HospitalDagestan State Medical UniversityNovosibirsk State Medical UniversityMoscow Research Oncological Institute named after P.A. Gertsen — Branch of National Medical Research Radiological CenterI.M. Sechenov First Moscow State University (Sechenov University)I.M. Sechenov First Moscow State University (Sechenov University)Kazan State Medical Academy — Branch Campus of the Russian Medical Academy of Continuous Professional EducationI.M. Sechenov First Moscow State University (Sechenov University)First Saint Petersburg State Medical University named after Academician I.P. Pavlov; Saint Petersburg State Pediatric Medical UniversityUral State Medical UniversityFederal Research Center “Krasnoyarsk Science Center of Siberian Branch of the Russian Academy of Sciences”, Separate Division “Scientific Research Institute of Medical Problems of the North”I.M. Sechenov First Moscow State University (Sechenov University)Aim. These recommendations are developed for practitioners in order to familiarize them with modern diagnostic methods, management features and pharmacotherapy of patients with gastroesophageal reflux disease (GERD).General provisions. GERD is the most common reason for patients to visit clinics. There are esophageal and extraesophageal manifestations of GERD. Patients' complaints of heartburn and regurgitation remain the most sensitive and specific clinical manifestations of GERD. The diagnosis of GERD is established on the basis of anamnestic data, instrumental examination (detection of reflux esophagitis during upper gastrointestinal endoscopy, detection of pathological gastroesophageal reflux with 24-hour pH-metry or/and 24-hour pH-impedance monitoring). Patients with suspected GERD and the absence of erosive and ulcerative changes in the mucous membrane of the esophagus or the presence of erosive esophagitis of Grade A according to Los Angeles Classification of Gastroesophageal Reflux Disease are recommended to conduct 24-hour pH-metry on PPI off to exclude or confirm the diagnosis of GERD. Patients with extraesophageal manifestations of GERD without classic symptoms (heartburn, regurgitation) are recommended to undergo 24-hour pH-impedance monitoring with discontinuation of proton pump inhibitor therapy. When deciding on surgical treatment, all patients need to perform high-resolution esophageal manometry and 24-hour pH-impedance monitoring. Complications of GERD include bleeding, strictures, Barrett’s esophagus and esophageal adenocarcinoma. The main groups of medications used in the treatment of GERD are proton pump inhibitors (PPIs), potassium-competitive acid blockers (P-CABs), alginates, antacids, and prokinetics. PPIs are the drugs of choice in the treatment of both symptoms of gastroesophageal reflux disease and existing erosive esophagitis. Combination therapy Rebamipide with PPIs increases the effectiveness of relief of GERD symptoms, as well as reduces the frequency of relapses.Conclusion. These clinical recommendations will improve the quality of medical care for patients with GERD.https://www.gastro-j.ru/jour/article/view/1395gastroesophageal reflux diseasegastroesophageal refluxextraesophageal manifestationsbarrett’s esophagushigh-resolution esophageal manometry24-hour ph-impedance monitoring |
| spellingShingle | V. T. Ivashkin A. S. Trukhmanov I. V. Maev O. M. Drapkina M. A. Livzan A. I. Martynov T. L. Lapina A. V. Paraskevova D. N. Andreev O. P. Alexeeva S. A. Alekseenko A. Yu. Baranovsky O. V. Zayratyants O. Yu. Zolnikova O. B. Dronova I. L. Kliaritskaia N. V. Korochanskaya Yu. A. Kucheryavyy S. N. Mammaev M. F. Osipenko S. S. Pirogov E. A. Poluektova D. E. Rumyantseva R. G. Sayfutdinov O. A. Storonova Yu. P. Uspenskiy I. B. Khlynov V. V. Tsukanov A. A. Sheptulin Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastroesophageal reflux disease gastroesophageal reflux extraesophageal manifestations barrett’s esophagus high-resolution esophageal manometry 24-hour ph-impedance monitoring |
| title | Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) |
| title_full | Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) |
| title_fullStr | Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) |
| title_full_unstemmed | Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) |
| title_short | Diagnosis and Treatment of Gastroesophageal Reflux Disease (Clinical Guidelines of the Russian Gastroenterological Association, Russian Scientific Medical Society of Internal Medicine, Russian Society for the Prevention of Noncommunicable Diseases, Scientific Community for Human Microbiome Research) |
| title_sort | diagnosis and treatment of gastroesophageal reflux disease clinical guidelines of the russian gastroenterological association russian scientific medical society of internal medicine russian society for the prevention of noncommunicable diseases scientific community for human microbiome research |
| topic | gastroesophageal reflux disease gastroesophageal reflux extraesophageal manifestations barrett’s esophagus high-resolution esophageal manometry 24-hour ph-impedance monitoring |
| url | https://www.gastro-j.ru/jour/article/view/1395 |
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