Innate immune recognition in hepatitis B virus infection
Hepatitis B virus (HBV) remains a major global public health challenge, with approximately 254 million individuals chronically infected worldwide. The interaction between HBV and the innate immune system has garnered significant attention within the scientific community, with numerous studies explor...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2492371 |
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| _version_ | 1849699272782512128 |
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| author | Aixin Li Zhengjun Yi Chunqiang Ma Bangyao Sun Li Zhao Xiaoming Cheng Lixia Hui Yuchen Xia |
| author_facet | Aixin Li Zhengjun Yi Chunqiang Ma Bangyao Sun Li Zhao Xiaoming Cheng Lixia Hui Yuchen Xia |
| author_sort | Aixin Li |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) remains a major global public health challenge, with approximately 254 million individuals chronically infected worldwide. The interaction between HBV and the innate immune system has garnered significant attention within the scientific community, with numerous studies exploring this relationship over the past several decades. While some research suggests that HBV infection activates the host’s innate immune response, other studies indicate that HBV suppresses innate immune signaling pathways. These conflicting findings underscore the complexity of the HBV-innate immunity interaction, which remains inadequately understood. This review aims to clarify this interplay by examining it from three perspectives: (a) studies showing HBV activation of innate immunity; (b) evidence suggesting HBV suppression of innate immunity; and (c) findings that support HBV’s role as a stealth virus. By synthesizing these perspectives, we aim to deepen the understanding of virus-host interactions that are crucial to HBV persistence and immune evasion, with potential implications for developing new therapeutic strategies for chronic HBV infection. |
| format | Article |
| id | doaj-art-a9dc589d9134470fa8a09f6de4576605 |
| institution | DOAJ |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-a9dc589d9134470fa8a09f6de45766052025-08-20T03:18:39ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2492371Innate immune recognition in hepatitis B virus infectionAixin Li0Zhengjun Yi1Chunqiang Ma2Bangyao Sun3Li Zhao4Xiaoming Cheng5Lixia Hui6Yuchen Xia7School of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaSchool of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaState Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, ChinaSchool of Laboratory Medicine, Shandong Second Medical University, Weifang, ChinaState Key Laboratory of Virology and Biosafety, Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Medical School, Wuhan University, Wuhan, ChinaHepatitis B virus (HBV) remains a major global public health challenge, with approximately 254 million individuals chronically infected worldwide. The interaction between HBV and the innate immune system has garnered significant attention within the scientific community, with numerous studies exploring this relationship over the past several decades. While some research suggests that HBV infection activates the host’s innate immune response, other studies indicate that HBV suppresses innate immune signaling pathways. These conflicting findings underscore the complexity of the HBV-innate immunity interaction, which remains inadequately understood. This review aims to clarify this interplay by examining it from three perspectives: (a) studies showing HBV activation of innate immunity; (b) evidence suggesting HBV suppression of innate immunity; and (c) findings that support HBV’s role as a stealth virus. By synthesizing these perspectives, we aim to deepen the understanding of virus-host interactions that are crucial to HBV persistence and immune evasion, with potential implications for developing new therapeutic strategies for chronic HBV infection.https://www.tandfonline.com/doi/10.1080/21505594.2025.2492371Hepatitis B virusHBVinnate immunityhepatocytesliver non-parenchymal cells |
| spellingShingle | Aixin Li Zhengjun Yi Chunqiang Ma Bangyao Sun Li Zhao Xiaoming Cheng Lixia Hui Yuchen Xia Innate immune recognition in hepatitis B virus infection Virulence Hepatitis B virus HBV innate immunity hepatocytes liver non-parenchymal cells |
| title | Innate immune recognition in hepatitis B virus infection |
| title_full | Innate immune recognition in hepatitis B virus infection |
| title_fullStr | Innate immune recognition in hepatitis B virus infection |
| title_full_unstemmed | Innate immune recognition in hepatitis B virus infection |
| title_short | Innate immune recognition in hepatitis B virus infection |
| title_sort | innate immune recognition in hepatitis b virus infection |
| topic | Hepatitis B virus HBV innate immunity hepatocytes liver non-parenchymal cells |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2492371 |
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