Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells

Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells

Abstract Sepsis-induced lung injury is a serious complication that contributes to the high morbidity and mortality rates in septic patients. This study aims to identify genes associated with sepsis-induced lung injury and evaluate the role of cathepsin B (CTSB) in this process. Here, by analyzing th...

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Bibliographic Details
Main Authors: Xiaobo Zhang, Zhuojun Deng, Xinyu Zhang, Qian Xu, Li Liu, Dong Yang, Zimeng Guo
Format: Article
Language:English
Published: BMC 2025-05-01
Series:European Journal of Medical Research
Subjects:
Sepsis
Cathepsin B
Inflammation
Pyroptosis
Gasdermin D
Online Access:https://doi.org/10.1186/s40001-025-02679-0
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