Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects
Clostridioides difficile previously known as Clostridium difficile is one of the three most potent human pathogens associated with antibiotic-associated diarrhoea and damage to the colon. Although advanced healthcare facilities with the development of new antibiotics are now available, these are ass...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | Medicine in Microecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097825000023 |
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| author | Chandrashekhar Singh Anjali Singh Deepjyoti Singh Richa Upadhyay |
| author_facet | Chandrashekhar Singh Anjali Singh Deepjyoti Singh Richa Upadhyay |
| author_sort | Chandrashekhar Singh |
| collection | DOAJ |
| description | Clostridioides difficile previously known as Clostridium difficile is one of the three most potent human pathogens associated with antibiotic-associated diarrhoea and damage to the colon. Although advanced healthcare facilities with the development of new antibiotics are now available, these are associated with either treatment failure or disease recurrence. Any reason that disturbs the microbiome such as antibiotic treatment, unbalanced diet, stress and chronic disease may allow C. difficile, to adhere, colonize, grow and reproduce and eventually cause disease recurrence. With increasing knowledge about the natural defence mechanism of microbiome against gut pathogens, interest in non-antibiotic alternatives like prebiotics, synbiotics, probiotics, and postbiotics is quickly evolving. The gut microenvironment can be suitably modified by using prebiotics and probiotics either alone or by using their mixture as synbiotics. The gut microbiome prevents pathogen adhesion either by physical competition or by the proliferation of anti-inflammatory and antimicrobial products. Besides, there are other possible methods such as faecal matter transplantation (FMT) and microbiome replacement therapies (MRT) for the repopulation of the gastrointestinal tract. In this article, we review current treatment strategies for C. difficile infection (CDI) using prebiotics, probiotics, synbiotics, postbiotic FMT, and MRT. The article will give useful insight into the current therapies of CDI and their future developments. |
| format | Article |
| id | doaj-art-a9d588a82a9e4f9f9f7448d3ad0a39cc |
| institution | DOAJ |
| issn | 2590-0978 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj-art-a9d588a82a9e4f9f9f7448d3ad0a39cc2025-08-20T03:14:30ZengElsevierMedicine in Microecology2590-09782025-06-012410012110.1016/j.medmic.2025.100121Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospectsChandrashekhar Singh0Anjali Singh1Deepjyoti Singh2Richa Upadhyay3Maharishi School of Science and Humanities, Maharishi University of Information Technology, Lucknow, 226013, Uttar Pradesh, IndiaLaboratory of Cell Cycles of Algae, Centre Algatech, Institute of Microbiology of Czech Academy of Sciences, Novaradaska, 23737981, Trebon, Czech RepublicDepartment of Entomology and Plant Pathology, North Carolina State University, USADepartment of Botany, Mihir Bhoj PG College, Dadri, GB Nagar, 203207, Uttar Pradesh, India; Corresponding author.Clostridioides difficile previously known as Clostridium difficile is one of the three most potent human pathogens associated with antibiotic-associated diarrhoea and damage to the colon. Although advanced healthcare facilities with the development of new antibiotics are now available, these are associated with either treatment failure or disease recurrence. Any reason that disturbs the microbiome such as antibiotic treatment, unbalanced diet, stress and chronic disease may allow C. difficile, to adhere, colonize, grow and reproduce and eventually cause disease recurrence. With increasing knowledge about the natural defence mechanism of microbiome against gut pathogens, interest in non-antibiotic alternatives like prebiotics, synbiotics, probiotics, and postbiotics is quickly evolving. The gut microenvironment can be suitably modified by using prebiotics and probiotics either alone or by using their mixture as synbiotics. The gut microbiome prevents pathogen adhesion either by physical competition or by the proliferation of anti-inflammatory and antimicrobial products. Besides, there are other possible methods such as faecal matter transplantation (FMT) and microbiome replacement therapies (MRT) for the repopulation of the gastrointestinal tract. In this article, we review current treatment strategies for C. difficile infection (CDI) using prebiotics, probiotics, synbiotics, postbiotic FMT, and MRT. The article will give useful insight into the current therapies of CDI and their future developments.http://www.sciencedirect.com/science/article/pii/S2590097825000023Gut microbiotaPolyphenolsFecal microbiota transplantAntibioticsC. difficile |
| spellingShingle | Chandrashekhar Singh Anjali Singh Deepjyoti Singh Richa Upadhyay Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects Medicine in Microecology Gut microbiota Polyphenols Fecal microbiota transplant Antibiotics C. difficile |
| title | Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects |
| title_full | Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects |
| title_fullStr | Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects |
| title_full_unstemmed | Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects |
| title_short | Potential therapeutic solution for Clostridioides difficile infection: Current scenario and future prospects |
| title_sort | potential therapeutic solution for clostridioides difficile infection current scenario and future prospects |
| topic | Gut microbiota Polyphenols Fecal microbiota transplant Antibiotics C. difficile |
| url | http://www.sciencedirect.com/science/article/pii/S2590097825000023 |
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