Chromatin-based memory as a self-stabilizing influence on cell identity
Abstract Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states. Through pervasive, local, feedback loops, chromatin memory enables cell states that were...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-024-03461-x |
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| _version_ | 1841544610397028352 |
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| author | Charles C. Bell Geoffrey J. Faulkner Omer Gilan |
| author_facet | Charles C. Bell Geoffrey J. Faulkner Omer Gilan |
| author_sort | Charles C. Bell |
| collection | DOAJ |
| description | Abstract Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states. Through pervasive, local, feedback loops, chromatin memory enables cell states that were initially unstable to become stable. Deeper appreciation of this self-stabilizing role for chromatin broadens our perspective of Waddington’s epigenetic landscape from a static surface with islands of stability shaped by evolution, to a plasticine surface molded by experience. With implications for the evolution of cell types, stabilization of resistant states in cancer, and the widespread plasticity of complex life. |
| format | Article |
| id | doaj-art-a9d1a62b13214017b52d53ff1cc6bf91 |
| institution | Kabale University |
| issn | 1474-760X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj-art-a9d1a62b13214017b52d53ff1cc6bf912025-01-12T12:25:57ZengBMCGenome Biology1474-760X2024-12-0125111310.1186/s13059-024-03461-xChromatin-based memory as a self-stabilizing influence on cell identityCharles C. Bell0Geoffrey J. Faulkner1Omer Gilan2Mater Research Institute, University of Queensland, TRI BuildingMater Research Institute, University of Queensland, TRI BuildingAustralian Centre for Blood Diseases, Monash UniversityAbstract Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states. Through pervasive, local, feedback loops, chromatin memory enables cell states that were initially unstable to become stable. Deeper appreciation of this self-stabilizing role for chromatin broadens our perspective of Waddington’s epigenetic landscape from a static surface with islands of stability shaped by evolution, to a plasticine surface molded by experience. With implications for the evolution of cell types, stabilization of resistant states in cancer, and the widespread plasticity of complex life.https://doi.org/10.1186/s13059-024-03461-x |
| spellingShingle | Charles C. Bell Geoffrey J. Faulkner Omer Gilan Chromatin-based memory as a self-stabilizing influence on cell identity Genome Biology |
| title | Chromatin-based memory as a self-stabilizing influence on cell identity |
| title_full | Chromatin-based memory as a self-stabilizing influence on cell identity |
| title_fullStr | Chromatin-based memory as a self-stabilizing influence on cell identity |
| title_full_unstemmed | Chromatin-based memory as a self-stabilizing influence on cell identity |
| title_short | Chromatin-based memory as a self-stabilizing influence on cell identity |
| title_sort | chromatin based memory as a self stabilizing influence on cell identity |
| url | https://doi.org/10.1186/s13059-024-03461-x |
| work_keys_str_mv | AT charlescbell chromatinbasedmemoryasaselfstabilizinginfluenceoncellidentity AT geoffreyjfaulkner chromatinbasedmemoryasaselfstabilizinginfluenceoncellidentity AT omergilan chromatinbasedmemoryasaselfstabilizinginfluenceoncellidentity |