Insights from Autopsy: Unveiling the Pathological Landscape of Acute Pancreatitis
Introduction: Acute pancreatitis (AP) is an inflammation of the pancreas that can lead to mortality, with the risk increasing according to disease severity. It can also cause sudden unexpected death. Aims and Objectives: This study aimed to examine the clinicopathological aspects of death from AP, f...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Marine Medical Society |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmms.jmms_94_24 |
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| Summary: | Introduction:
Acute pancreatitis (AP) is an inflammation of the pancreas that can lead to mortality, with the risk increasing according to disease severity. It can also cause sudden unexpected death.
Aims and Objectives:
This study aimed to examine the clinicopathological aspects of death from AP, focusing on common etiology and postmortem histomorphological patterns.
Materials and Methods:
The autopsy files and hematoxylin and eosin-stained slides of all cases from January 2017 to August 2023 were studied.
Results:
AP was established as the cause of death in 23 (7.3%) of 315 autopsies conducted during the study period. Most deaths occurred in the age group of 30–39 years. Alcohol was identified as the cause in 9 (39.1%) patients, whereas biliary etiology was found in 3 (13%) patients. Hyperlipidemia was observed in 2 (8.7%) patients, and 5 (21.7%) cases had underlying diabetes mellitus. In 9 (39.1%) patients, no clearly defined etiologic association could be established, and they were considered “idiopathic.” Nineteen patients (82.61%) died in the early phase, primarily due to multiorgan dysfunction syndrome, whereas 4 (17.39%) patients died in the late phase, primarily due to sepsis. Hemorrhagic necrotizing pancreatitis was present in all patients with equal frequency across all etiologic subgroups.
Conclusion:
This study is one of the few in India to examine 23 autopsy cases of AP, providing valuable insights into the diverse manifestations and implications of this condition. |
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| ISSN: | 0975-3605 2589-1235 |