Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process
Polyanhydrides have been used as drug delivery systems to achieve a long-term delivery due to its hydrophobicity and surface erosion degradation behavior. In order to develop a simple, economical, and rapid approach to synthesize polyanhydrides, we prepared a series of polyether-anhydride membranes...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Polymer Science |
| Online Access: | http://dx.doi.org/10.1155/2013/916571 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559021669744640 |
|---|---|
| author | Anxin Dong Tao Zhang |
| author_facet | Anxin Dong Tao Zhang |
| author_sort | Anxin Dong |
| collection | DOAJ |
| description | Polyanhydrides have been used as drug delivery systems to achieve a long-term delivery due to its hydrophobicity and surface erosion degradation behavior. In order to develop a simple, economical, and rapid approach to synthesize polyanhydrides, we prepared a series of polyether-anhydride membranes composed of different mass fractions of sebacic acid, polyethylene glycol dimethacrylate, and poly(tetramethylene oxide) dimethacrylate by ultraviolet curing process. The chemical structure and thermal properties of target polyanhydrides were characterized, while the paclitaxel releases from the polymer matrix were evaluated by HPLC. The results demonstrated that the UV-curing process is a good method to synthesize the target polymers in a short time, and the paclitaxel release procedure can be controlled by changing the component in the copolymers. |
| format | Article |
| id | doaj-art-a9cbc74e4d3b453ea25fc248ff317064 |
| institution | Kabale University |
| issn | 1687-9422 1687-9430 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Polymer Science |
| spelling | doaj-art-a9cbc74e4d3b453ea25fc248ff3170642025-02-03T01:31:07ZengWileyInternational Journal of Polymer Science1687-94221687-94302013-01-01201310.1155/2013/916571916571Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing ProcessAnxin Dong0Tao Zhang1College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, ChinaCollege of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, ChinaPolyanhydrides have been used as drug delivery systems to achieve a long-term delivery due to its hydrophobicity and surface erosion degradation behavior. In order to develop a simple, economical, and rapid approach to synthesize polyanhydrides, we prepared a series of polyether-anhydride membranes composed of different mass fractions of sebacic acid, polyethylene glycol dimethacrylate, and poly(tetramethylene oxide) dimethacrylate by ultraviolet curing process. The chemical structure and thermal properties of target polyanhydrides were characterized, while the paclitaxel releases from the polymer matrix were evaluated by HPLC. The results demonstrated that the UV-curing process is a good method to synthesize the target polymers in a short time, and the paclitaxel release procedure can be controlled by changing the component in the copolymers.http://dx.doi.org/10.1155/2013/916571 |
| spellingShingle | Anxin Dong Tao Zhang Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process International Journal of Polymer Science |
| title | Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process |
| title_full | Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process |
| title_fullStr | Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process |
| title_full_unstemmed | Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process |
| title_short | Paclitaxel Release from Polyether-Anhydrides Prepared with UV-Curing Process |
| title_sort | paclitaxel release from polyether anhydrides prepared with uv curing process |
| url | http://dx.doi.org/10.1155/2013/916571 |
| work_keys_str_mv | AT anxindong paclitaxelreleasefrompolyetheranhydridespreparedwithuvcuringprocess AT taozhang paclitaxelreleasefrompolyetheranhydridespreparedwithuvcuringprocess |