Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up
Background: Antiretroviral triple therapy has considerably reduced morbidity and mortality in people living with HIV and is the standard-of-care treatment. However, it is lifelong and linked to long-term side effects and adherence problems. Methods: Here, we report long-term virological and immunolo...
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MDPI AG
2024-11-01
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| author | Massimiliano Lanzafame Emanuela Lattuada Andrea Delama Giovanni Mori Sandro Vento |
| author_facet | Massimiliano Lanzafame Emanuela Lattuada Andrea Delama Giovanni Mori Sandro Vento |
| author_sort | Massimiliano Lanzafame |
| collection | DOAJ |
| description | Background: Antiretroviral triple therapy has considerably reduced morbidity and mortality in people living with HIV and is the standard-of-care treatment. However, it is lifelong and linked to long-term side effects and adherence problems. Methods: Here, we report long-term virological and immunological outcome in 12 virally suppressed people on short-cycle therapy with bictegravir/emtricitabine/tenofovir alafenamide administered five days a week (Monday to Friday). Results: All patients, after a long term follow-up, were virally suppressed Conclusions: In the wait for new long-acting antiretroviral drugs and new antiretroviral formulations, short-cycle therapy has proven to be a safe and effective alternative to the standard daily antiretroviral regimen for individuals living with HIV who are virologically suppressed. |
| format | Article |
| id | doaj-art-a9c8e3c322f642ffa672e5a0a4a43d46 |
| institution | OA Journals |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-a9c8e3c322f642ffa672e5a0a4a43d462025-08-20T01:53:49ZengMDPI AGBiomedicines2227-90592024-11-011211262010.3390/biomedicines12112620Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-UpMassimiliano Lanzafame0Emanuela Lattuada1Andrea Delama2Giovanni Mori3Sandro Vento4Unit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, ItalyUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, ItalyUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, ItalyUnit of Infectious Diseases, Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari, 38122 Trento, ItalyFaculty of Medicine, University of Puthisastra, Phnom Penh 12211, CambodiaBackground: Antiretroviral triple therapy has considerably reduced morbidity and mortality in people living with HIV and is the standard-of-care treatment. However, it is lifelong and linked to long-term side effects and adherence problems. Methods: Here, we report long-term virological and immunological outcome in 12 virally suppressed people on short-cycle therapy with bictegravir/emtricitabine/tenofovir alafenamide administered five days a week (Monday to Friday). Results: All patients, after a long term follow-up, were virally suppressed Conclusions: In the wait for new long-acting antiretroviral drugs and new antiretroviral formulations, short-cycle therapy has proven to be a safe and effective alternative to the standard daily antiretroviral regimen for individuals living with HIV who are virologically suppressed.https://www.mdpi.com/2227-9059/12/11/2620antiretroviral treatmentshort-cycle therapyHIVvirologically suppressed peoplebictegravir |
| spellingShingle | Massimiliano Lanzafame Emanuela Lattuada Andrea Delama Giovanni Mori Sandro Vento Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up Biomedicines antiretroviral treatment short-cycle therapy HIV virologically suppressed people bictegravir |
| title | Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up |
| title_full | Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up |
| title_fullStr | Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up |
| title_full_unstemmed | Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up |
| title_short | Short-Cycle Therapy with Bictegravir/Emtricitabine/Tenofovir Alafenamide in a Small Cohort of Virally Suppressed People Living with HIV: A Long-Term Follow-Up |
| title_sort | short cycle therapy with bictegravir emtricitabine tenofovir alafenamide in a small cohort of virally suppressed people living with hiv a long term follow up |
| topic | antiretroviral treatment short-cycle therapy HIV virologically suppressed people bictegravir |
| url | https://www.mdpi.com/2227-9059/12/11/2620 |
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