Development and characterization of fluorescent cholesteryl probes with enhanced solvatochromic and pH-sensitive properties for live-cell imaging

Development and characterization of fluorescent cholesteryl probes with enhanced solvatochromic and pH-sensitive properties for live-cell imaging

Abstract We present novel fluorescent cholesteryl probes (CNDs) with a modular design based on the solvatochromic 1,8-phthalimide scaffold. We have explored how different modules—linkers and head groups—affect the ability of these probes to integrate into lipid membranes and how they distribute intr...

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Bibliographic Details
Main Authors: Vicente Rubio, Nicholas McInchak, Genesis Fernandez, Dana Benavides, Diana Herrera, Catherine Jimenez, Haylee Mesa, Jonathan Meade, Qi Zhang, Maciej J. Stawikowski
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Cholesterol
Fluorescent reporter
pH-sensitivity
Fluorescence microscopy
Membrane
Lipid rafts
Online Access:https://doi.org/10.1038/s41598-024-80958-2
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