Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia?
Chemotherapy-induced thrombocytopenia (CIT) is a common complication of cancer therapy for solid tumors that results in increased bleeding risk and chemotherapy dose reductions, treatment delays, and agent discontinuation. Unlike other chemotherapy-induced cytopenias, CIT remains without any license...
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Elsevier
2025-07-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2475037925003048 |
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| author | Hanny Al-Samkari |
| author_facet | Hanny Al-Samkari |
| author_sort | Hanny Al-Samkari |
| collection | DOAJ |
| description | Chemotherapy-induced thrombocytopenia (CIT) is a common complication of cancer therapy for solid tumors that results in increased bleeding risk and chemotherapy dose reductions, treatment delays, and agent discontinuation. Unlike other chemotherapy-induced cytopenias, CIT remains without any licensed therapies in most of the world. Multiple thrombopoietin receptor agonists (TPO-RAs) have been approved for other thrombocytopenic indications, however, and are widely available, offering an accessible option for CIT management. In this Research and Practice in Thrombosis and Haemostasis Forum article, the historical reasons for the current state of CIT treatment are explained, the potential benefits and risks of TPO-RA use in CIT are discussed, and the patient populations who are likely to benefit and not benefit from TPO-RA support are described. |
| format | Article |
| id | doaj-art-a9c03493a3bd47c5ae19d104e3c6d343 |
| institution | Kabale University |
| issn | 2475-0379 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj-art-a9c03493a3bd47c5ae19d104e3c6d3432025-08-20T03:43:44ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792025-07-019510298010.1016/j.rpth.2025.102980Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia?Hanny Al-Samkari0Division of Classical Hematology, Mass General Brigham Cancer Institute, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA; Correspondence Hanny Al-Samkari, Division of Hematology Oncology, Massachusetts General Hospital, Bartlett Hall Ext Office 133, 55 Fruit St, Boston, MA 02114, USA.Chemotherapy-induced thrombocytopenia (CIT) is a common complication of cancer therapy for solid tumors that results in increased bleeding risk and chemotherapy dose reductions, treatment delays, and agent discontinuation. Unlike other chemotherapy-induced cytopenias, CIT remains without any licensed therapies in most of the world. Multiple thrombopoietin receptor agonists (TPO-RAs) have been approved for other thrombocytopenic indications, however, and are widely available, offering an accessible option for CIT management. In this Research and Practice in Thrombosis and Haemostasis Forum article, the historical reasons for the current state of CIT treatment are explained, the potential benefits and risks of TPO-RA use in CIT are discussed, and the patient populations who are likely to benefit and not benefit from TPO-RA support are described.http://www.sciencedirect.com/science/article/pii/S2475037925003048avatrombopagbleedingchemotherapy-induced thrombocytopeniarelative dose intensityromiplostimthrombopoietin receptor agonist |
| spellingShingle | Hanny Al-Samkari Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? Research and Practice in Thrombosis and Haemostasis avatrombopag bleeding chemotherapy-induced thrombocytopenia relative dose intensity romiplostim thrombopoietin receptor agonist |
| title | Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? |
| title_full | Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? |
| title_fullStr | Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? |
| title_full_unstemmed | Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? |
| title_short | Should thrombopoietin receptor agonists be used for chemotherapy-induced thrombocytopenia? |
| title_sort | should thrombopoietin receptor agonists be used for chemotherapy induced thrombocytopenia |
| topic | avatrombopag bleeding chemotherapy-induced thrombocytopenia relative dose intensity romiplostim thrombopoietin receptor agonist |
| url | http://www.sciencedirect.com/science/article/pii/S2475037925003048 |
| work_keys_str_mv | AT hannyalsamkari shouldthrombopoietinreceptoragonistsbeusedforchemotherapyinducedthrombocytopenia |