Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model

Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model

Abstract Background Osteoarthritis (OA) is a common cause of disability around the world, but the pathophysiology is still poorly understood. The study sought to investigate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) injection in OA, with a focus on cartilage degradation. Methods...

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Bibliographic Details
Main Authors: Yanqun Li, Qipeng Han, Shayan Chen, Wenlong Huang, Yanqing Chen, Zhihuang Wu, Fengming Tan, Muyun Liu, Jiangying Zou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
MSCs
Osteoarthritis
Molecular mechanism
Metalloproteases
Online Access:https://doi.org/10.1186/s12891-025-08797-4
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